文献类型： 外文期刊
第一作者： Shi, Enjuan
作者： Shi, Enjuan;Wang, Xiaoqin;Jing, Huili;Xu, Yayuan;Feng, Lei;Li, Dajing;Dai, Zhuqing;Shi, Enjuan;He, Fatao;Wang, Xiaoqin;Jing, Huili
作者机构：
关键词： Chitosan; beta-Carotene; Retinitis pigmentosa; Gut microbiota
期刊名称：INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES （ 影响因子：8.2； 五年影响因子：7.8 ）
ISSN： 0141-8130
年卷期： 2024 年 268 卷
页码：
收录情况： SCI
摘要： In this study, N -Methyl-N-nitrosourea (MNU) was intraperitoneally injected to construct a mouse retinitis pigmentosa (RP) model to evaluate the protective effect of chitosan and beta- carotene on RP. The results demonstrated that chitosan synergized with beta- carotene significantly reduced retinal histopathological structural damage in RP mice. The co-treatment group of beta- carotene and chitosan restored the retinal thickness and outer nuclear layer thickness better than the group treated with the two alone, and the thickness reached the normal level. The content of beta- carotene and retinoids in the liver of chitosan and beta- carotene co-treated group increased by 46.75 % and 20.69 %, respectively, compared to the beta- carotene group. Chitosan and beta- carotene supplement suppressed the expressions of Bax, Calpain2, Caspase3, NF- kappa B, TNF-alpha, IL-6, and IL-1 beta, and promoted the up-regulation of Bcl2. Chitosan and beta- carotene interventions remarkably contributed to the content of SCFAs and enhanced the abundance of Ruminococcaceae , Rikenellaceae , Odoribacteraceae and Helicobacteraceae . Correlation analysis demonstrated a strong association between gut microbiota and improvement in retinitis pigmentosa. This study will provide a reference for the study of the gut-eye axis.
分类号：
- 相关文献
作者其他论文 更多>>
-
Preparation of a novel ATP liposome and its regulation of postharvest senescence in Agaricus bisporus
作者：Jiang, Xin;Han, Jiali;Feng, Lei;Wang, Jia;Wang, Xiangyou;Guo, Yanyin;Li, Ling;Chen, Cunkun;Chen, Cunkun;Kitazawa, Hiroaki
关键词：Agaricus bisporus; ATP; Egg yolk lecithin; Liposome; Preservation
-
Effect of Plasma-Activated Water (PAW) on the Postharvest Quality of Shepherd's Purse (Capsella bursa-pastoris)
作者：Xiong, Lingming;Feng, Lei;Nie, Meimei;Li, Dajing;Zhang, Zhongyuan;Liu, Chunquan;Dai, Zhuqing;Xiao, Yadong;Xu, Yayuan
关键词：shepherd's purse; plasma-activated water; postharvest quality; microbial growth; aroma characteristics
-
Lutein-stevioside nanoparticle attenuates H2O2-induced oxidative damage in ARPE cells
作者：Dai, Zhuqing;Nie, Meimei;Chen, Ye;Song, Jiangfeng;Xu, Yayuan;Zhang, Zhongyuan;Li, Dajing;Zhang, Zhongyuan;Zhang, Guodong;Zhang, Xing;Yan, Shumo
关键词：Lutein; Stevioside; Antioxidant; Human retinal pigment epithelial cell; Mechanism
-
Comprehensive analysis of the aldehyde dehydrogenase gene family in Phaseolus vulgaris L. and their response to saline-alkali stress
作者：Wang, Xiaoqin;Wu, Mingxu;Yu, Song;Zhai, Lingxia;Zhu, Xuetian;Yu, Lihe;Zhang, Yifei;Zhai, Lingxia;Yu, Song;Yu, Lihe;Zhang, Yifei
关键词：common bean; aldehyde dehydrogenase; abiotic stress; saline-alkali stress; expression pattern
-
Identification of Trichderma harzianum in postharvest Agaricus bisporus and a novel control approach using eucalyptus essential oil emulsion
作者：Han, Jiali;Jiang, Xin;Feng, Lei;Wang, Jia;Wang, Xiangyou;Guo, Yanyin;Li, Ling;Zhou, Qingxin;Kitazawa, Hiroaki
关键词：Agaricus bisporus; Antifungal mechanisms; Eucalyptus essential oil; Postharvest disease; Trichoderma harzianum species complex
-
Study on the colloidal and emulsifying properties of different whole-component plant-based particles
作者：Hao, Chunxue;Bao, Yihong;Hao, Chunxue;Xu, Yayuan;Dai, Zhuqing;Zhang, Zhongyuan;Feng, Lei;Li, Dajing
关键词：Whole-component; Colloidal particles; Pickering emulsions; Emulsifying property; Stability
-
Fire effects on soil CH4 and N2O fluxes across terrestrial ecosystems
作者：Guo, Jiahuan;Feng, Huili;Peng, Changhui;Kneeshaw, Daniel;Roberge, Gabrielle;Peng, Changhui;Du, Juan;Wang, Weifeng;Pan, Chang;Feng, Lei;Chen, Anping;Chen, Anping
关键词：Fire; Soil; Methane; Nitrous oxide; Climate change; Terrestrial ecosystems
