Gene expression profiling of SIRT1, FoxO1, and PPAR gamma in backfat tissues and subcutaneous adipocytes of Lilu bulls

文献类型： 外文期刊

第一作者： Song, Enliang

作者： Song, Enliang

作者机构：

关键词： Backfat tissue;Subcutaneous adipocytes;Sirtuin 1;Forkhead box O1;Peroxisome proliferator-activated receptor-gamma

期刊名称：MEAT SCIENCE （ 影响因子：5.209； 五年影响因子：5.305 ）

ISSN： 0309-1740

年卷期： 2014 年 96 卷 2 期

页码：

收录情况： SCI

摘要： The temporal pattern of gene expression of sirtuin 1 (SIRT1), forkhead box O1 (FoxO1), and peroxisome proliferator-activated receptor-gamma (PPAR gamma) in differentiating bovine preadipocytes and in backfat tissue from Lilu bulls 12,18,24, and 30 months old was investigated using real-time quantitative PCR; Carcass characteristics and adipocyte diameters were also measured. The upregulation of PPAR gamma and the downregulation of SIRT1 and FoxO1 were observed in the backfat tissue of Lilu cattle with increasing age. Moreover, the results showed that fat accumulation in Lilu cattle may primarily be related to an increase in mature fat cell numbers after 18 months of age. The present study indicates SIRT1 may play an important role in the development of bovine adipose tissue in vivo. Although SIRT1, FoxO1, and PPAR gamma expression appeared to be nonlinear during the stages of preadipocyte differentiation, these genes play an important role during bovine adipocyte development in Lilu cattle. (C) 2013 Elsevier Ltd. All rights reserved.

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