Effects of fucosylated milk of goat and mouse on Helicobacter pylori binding to Lewis b antigen

文献类型： 外文期刊

第一作者： Xu, Hong-Tao

作者： Xu, Hong-Tao;Zhao, Zhi-Hui;Yu, Shu-Yang;Dai, Yun-Ping;Wang, Li-Li;Niu, Hui-Ling;Li, Ning;Zhao, Yao-Feng;Hammarstrom, Lennart;Lian, Zheng-Xing;Fan, Bao-Liang;Boren, Thomas

作者机构：

期刊名称：WORLD JOURNAL OF GASTROENTEROLOGY （ 影响因子：5.742； 五年影响因子：5.044 ）

ISSN： 1007-9327

年卷期： 2004 年 10 卷 14 期

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收录情况： SCI

摘要： AIM: To evaluate the effects of animal milk containing fucosylated antigens on Helicobacter pylori ( H pylori) binding to Lewis b antigen. METHODS: A mammary gland expression vector containing human alpha 1-3/4-fucosyltransferase cDNA sequences was constructed. Transient expression of human alpha 1-3/4-fucosyltransferase cDNA in goat mammary cell and establishment of transgenic mice were performed. The adhesion inhibitory properties of milk samples were analyzed by using H pylori. RESULTS: Goat milk samples were found to inhibit bacterial binding to Lewis b antigen. The highest inhibition was observed 42 h after injection of the plasmid. The binding activity of H pylori to Lewis b antigen reduced mostly, by 83%, however milk samples from transgenic mice did not inhibit H pylori binding to Lewis b antigen. CONCLUSION: The use of "humanized" animal milk produced by the transgenic introduction of fucosylated antigen can perhaps provide an alternative therapy and preventive measure for H pylori infection.

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