Effect of an exon 1 mutation in the myostatin gene on the growth traits of the Bian chicken

文献类型: 外文期刊

第一作者: Zhang, G. X.

作者: Zhang, G. X.;Zhao, X. H.;Wang, J. Y.;Ding, F. X.;Zhang, L.

作者机构:

关键词: chicken;growth traits;myostatin gene;PCR-restriction fragment length polymorphism

期刊名称:ANIMAL GENETICS ( 影响因子:3.169; 五年影响因子:3.058 )

ISSN: 0268-9146

年卷期: 2012 年 43 卷 4 期

页码:

收录情况: SCI

摘要: Myostatin (MSTN), or growth and differentiation factor 8 (GDF8), is a member of the transforming growth factor (TGF)-beta superfamily. This family functions as a negative regulator of skeletal muscle development and growth in mammals. Single-nucleotide polymorphisms in exon 1 of the Bian chicken myostatin gene were detected by polymerase chain reaction-restriction fragment length polymorphism. A mutation (c.234G>A) in exon 1 was found. Female Bian chickens of genotypes AA and GA had significantly higher body weights than those of genotype GG (P < 0.05 or P < 0.01) from 6 to 18 weeks of age. These results suggested that the mutation c.234G>A in exon 1 could be used as a genetic marker for Bian chicken growth traits.

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