Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens

文献类型： 外文期刊

第一作者： Zhang, Xinheng

作者： Zhang, Xinheng;Yan, Yiming;Lei, Xiaoya;Dai, Zhenkai;Li, Xinjian;Chen, Weiguo;Lin, Wencheng;Chen, Feng;Ma, Jingyun;Xie, Qingmei;Zhang, Xinheng;Yan, Yiming;Lei, Xiaoya;Dai, Zhenkai;Li, Xinjian;Chen, Weiguo;Lin, Wencheng;Chen, Feng;Ma, Jingyun;Xie, Qingmei;Li, Aijun;Zhang, Huanmin;Zhang, Xinheng;Yan, Yiming;Lei, Xiaoya;Dai, Zhenkai;Li, Xinjian;Chen, Weiguo;Lin, Wencheng;Chen, Feng;Ma, Jingyun;Xie, Qingmei;Zhang, Xinheng;Chen, Weiguo;Lin, Wencheng;Chen, Feng;Ma, Jingyun;Xie, Qingmei

作者机构：

关键词： circular RNA;ALV-J-resistant chickens;circular-seq;tumor

期刊名称：ONCOTARGET （ 影响因子：5.168； 五年影响因子：5.312 ）

ISSN： 1949-2553

年卷期： 2017 年 8 卷 21 期

页码：

收录情况： SCI

摘要： Avian leukosis virus subgroup (ALV-J) is an oncogenic neoplasm-inducing retrovirus that causes significant economic losses in the poultry industry. Recent studies have demonstrated circular RNAs (circRNAs) are implicated in pathogenic processes; however, no research has indicated circRNAs are involved in resistance to disease. In this study, over 1800 circRNAs were detected by circRNA sequencing of liver tissues from ALV-J-resistant (n = 3) and ALV-J-susceptible chickens (n = 3). 32 differentially expressed circRNAs were selected for analyzing including 12 upregulated in ALV-J-resistant chickens and 20 upregulated in ALV-J-susceptible chickens, besides, the top five microRNAs (miRNAs) for 12 upregulated circRNAs in ALV-J-resistant chickens were analyzed. Gene ontology and KEGG pathway analyses were performed for miRNA target genes, the predicted genes were mainly involved in immune pathways. This study provides the first evidence that circRNA alterations are involved in resistance to ALV-J-induced tumor formation. We propose circRNAs may help to mediate tumor induction and development in chickens.

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