Antioxidant and Anti-Inflammatory Properties of Rubber Seed Oil in Lipopolysaccharide-Induced RAW 267.4 Macrophages

文献类型： 外文期刊

第一作者： Liu, Jing

作者： Liu, Jing;Zhao, Lulu;Cai, Hongying;Zhao, Zitao;Wu, Yongbao;Wen, Zhiguo;Yang, Peilong

作者机构：

关键词： rubber seed oil; antioxidant; anti-inflammatory; Nrf2 signal pathway; NF-kappa B signal pathway

期刊名称：NUTRIENTS （ 影响因子：6.706； 五年影响因子：7.185 ）

ISSN：

年卷期： 2022 年 14 卷 7 期

页码：

收录情况： SCI

摘要： Rubber seed oil (RSO) is a typical PUFA-enriched plant oil, but it has not been widely used as a healthy edible oil resource due to the lack of understanding of its nutritional values, health biological effects, and action mechanisms. This work was conducted to characterize the basic physicochemical properties, evaluate the antioxidant and anti-inflammatory properties, and explore the involved mechanisms of RSO in LPS-induced RAW 264.7 cells. In the present study, the basic physicochemical parameters of RSO indicated that RSO has good qualities as a potential edible plant oil resource. In LPS-induced macrophages, RSO supplementation displayed a significant antioxidant effect by decreasing ROS and MDA levels as well as elevating T-AOC. In addition, RSO supplementation showed an anti-inflammatory effect by reducing the production of NO, IL-1 beta, IL-6, and TNF-alpha while promoting the production of IL-10. Moreover, RSO supplementation decreased the mRNA expression of IL-6, IL-1 beta, TNF-alpha, iNOS, and MCP-1 genes while increasing the mRNA expression of the IL-10 gene. Furthermore, RSO supplementation increased Nrf2 protein expression and up-regulated antioxidant genes (HO-1 and NQO-1), which was accompanied by the decrease in TLR4 protein expression and NF-kappa B p65 phosphorylation as well as I kappa B alpha phosphorylation. This study provided some insight into the applications of RSO as a healthy edible oil resource.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序