GADD45 beta, an anti-tumor gene, inhibits avian leukosis virus subgroup J replication in chickens

文献类型: 外文期刊

第一作者: Zhang, Xinheng

作者: Zhang, Xinheng;Yan, Zhuanqiang;Li, Xinjian;Lin, Wencheng;Dai, Zhenkai;Yan, Yiming;Lu, Piaopiao;Chen, Weiguo;Chen, Feng;Ma, Jingyun;Xie, Qingmei;Zhang, Xinheng;Yan, Zhuanqiang;Li, Xinjian;Lin, Wencheng;Dai, Zhenkai;Yan, Yiming;Lu, Piaopiao;Chen, Weiguo;Chen, Feng;Ma, Jingyun;Xie, Qingmei;Zhang, Xinheng;Yan, Zhuanqiang;Li, Xinjian;Lin, Wencheng;Dai, Zhenkai;Yan, Yiming;Lu, Piaopiao;Chen, Weiguo;Chen, Feng;Ma, Jingyun;Xie, Qingmei;Zhang, Xinheng;Li, Xinjian;Lin, Wencheng;Dai, Zhenkai;Yan, Yiming;Lu, Piaopiao;Chen, Weiguo;Chen, Feng;Ma, Jingyun;Xie, Qingmei;Lin, Wencheng;Chen, Weiguo;Chen, Feng;Xie, Qingmei;Zhang, Huanmin

作者机构:

关键词: ALV-J;RNA-Seq;differentially expressed genes;GADD45 beta;viral replication

期刊名称:ONCOTARGET ( 影响因子:5.168; 五年影响因子:5.312 )

ISSN: 1949-2553

年卷期: 2016 年 7 卷 42 期

页码:

收录情况: SCI

摘要: Avian leukosis virus subgroup J (ALV-J) is a retroviruses that induces neoplasia, hepatomegaly, immunosuppression and poor performance in chickens. The tumorigenic and pathogenic mechanisms of ALV-J remain a hot topic. To explore anti-tumor genes that promote resistance to ALV-J infection in chickens, we bred ALV-J resistant and susceptible chickens (F3 generation). RNA-sequencing (RNA-Seq) of liver tissue from the ALV-J resistant and susceptible chickens identified 216 differentially expressed genes; 88 of those genes were up-regulated in the ALV-J resistant chickens (compared to the susceptible ones). We screened for significantly up-regulated genes (P < 0.01) of interest in the ALV-J resistant chickens, based on their involvement in biological signaling pathways. Functional analyses showed that overexpression of GADD45 beta inhibited ALV-J replication. GADD45 beta could enhance defense against ALV-J infection and may be used as a molecular marker to identify ALV-J infections.

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