Dibutyryl-cAMP affecting fat deposition of finishing pigs by decreasing the inflammatory system related to insulin sensitive or lipolysis

文献类型： 外文期刊

第一作者： Ma, Xianyong

作者： Ma, Xianyong;Fang, Wei;Jiang, Zongyong;Wang, Li;Yang, Xuefen;Gao, Kaiguo;Ma, Xianyong;Fang, Wei;Jiang, Zongyong;Wang, Li;Yang, Xuefen;Gao, Kaiguo;Ma, Xianyong;Fang, Wei;Jiang, Zongyong;Wang, Li;Yang, Xuefen;Gao, Kaiguo;Ma, Xianyong;Fang, Wei;Jiang, Zongyong;Wang, Li;Yang, Xuefen;Gao, Kaiguo;Ma, Xianyong;Fang, Wei;Jiang, Zongyong;Wang, Li;Yang, Xuefen;Gao, Kaiguo

作者机构：

关键词： Backfat thickness;Adipocyte cell;Gene microarray;Inflammatory system;Endocrine system

期刊名称：GENES AND NUTRITION （ 影响因子：5.523； 五年影响因子：4.4 ）

ISSN： 1865-3499

年卷期： 2016 年 11 卷

页码：

收录情况： SCI

摘要： Background: The mechanism of db-cAMP regulating fat deposition and improving lean percentage is unclear and needs to be further studied. Methods: Eighteen 100-day-old Duroc x Landrance x Large White barrows (49.75 +/- 0.75 kg) were used for experiment 1, and 15 eighteen 135-day-old barrows (78.34 +/- 1.22 kg) were used for experiment 2 to investigate the effects of dietary dibutyryl-cAMP (db-cAMP) on fat deposition in finishing pigs. Pigs were fed with a corn-soybean meal-based diet supplemented with 0 or 15 mg/kg db-cAMP, and both experiments lasted 35 days, respectively. Results: The results showed that db-cAMP decreased the backfat thickness, backfat percentage, and diameter of backfat cells without changing the growth performance or carcass characteristics in both experiments, and this effect was more marked in experiment 1 than in experiment 2; db-cAMP enhanced the activity of the growth hormone-insulin-like growth factor-1 (GH-IGF-1) axis and pro-opiomelanocortin (POMC) system in both experiments, which suppressed the accumulation of backfat deposition; microarray analysis showed that db-cAMP suppressed the inflammatory system within the adipose tissue related to insulin sensitivity, which also reduced fat synthesis. Conclusions: In summary, the effect of db-cAMP on suppressing fat synthesis and accumulation is better in the earlier phase than in the later phase of finishing pigs, and db-cAMP plays this function by increasing the activity of the GH-IGF-1 axis and POMC system, while decreasing the inflammatory system within the adipose tissue related to insulin sensitive or lipolysis.

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