The SNPs C.513A > T in the MHC B-F gene and rs15001532 in the SPOCK1 gene are associated with Salmonella pullorum disease resistance in chickens
文献类型: 外文期刊
第一作者: Zhang Ze-tang
作者: Zhang Ze-tang;Gan Jian-kang;Zhang Wen-wu;Zhang De-xiang;Zhang Xi-quan;Luo Qing-bin;Zhang Ze-tang;Gan Jian-kang;Zhang Wen-wu;Zhang De-xiang;Zhang Xi-quan;Luo Qing-bin;Gan Jian-kang
作者机构:
关键词: MHC B-F gene;SPOCK1 gene;SNPs;Salmonella pullorum;partridge chicken
期刊名称:JOURNAL OF INTEGRATIVE AGRICULTURE ( 影响因子:2.848; 五年影响因子:2.979 )
ISSN: 2095-3119
年卷期: 2016 年 15 卷 8 期
页码:
收录情况: SCI
摘要: This study was designed to identify molecular markers single nucleotide polymorphisms (SNPs) of MHC B-F gene and SPOCK1) associated with Salmonella pullorum disease susceptibility/resistance. A two-stage case-control association study was used. In the first study, a small population comprising 401 Partridge chickens (201 cases and 200 controls) was used, and a total of 118 SNPs genotyped. In the second study, a bigger population comprising 1 075 Partridge chickens (527 cases and 548 controls) was used, and SNPs with significant effect determined in the first study were further analysed. In the first study, 8 SNPs were significantly associated with S. Pullorum disease susceptibility/resistance, however, after further analysis, only the SNPs rs15001532 and C.513A>T were found to be significantly associated with S. Pullorum disease susceptibility/resistance. The relative risk test demonstrated that the AA genotype of rs15001532 resulted in a higher risk of S. Pullorum infection, whereas birds with the TT genotype of C.513A>T were more susceptible to S. Pullorum infection. This research was based on the researches on human complex diseases. With help of these train of thoughts, some common animal diseases can be studied effectively and the process of candidate gene research for animal disease can be improved.
分类号:
- 相关文献
作者其他论文 更多>>
-
Incorporating genomic annotation into single-step genomic prediction with imputed whole-genome sequence data
作者:Teng Jin-yan;Ye Shoo-pan;Chen Zi-tao;Diao Shu-qi;Yuan Xiao-long;Zhang Hao;Li Jia-qi;Zhang Xi-quan;Zhang Zhe;Gao Ning;Li Xiu-jin
关键词:genomic selection; prior information; sequencing data; genotype imputation; haplotype
-
An efficient and rapid method to detect and verify natural antisense transcripts of animal genes
作者:Zhang Li;Zhao Rui;Xiao Mei;An Li-long;Lin Shu-dai;Li Bi-xiao;Qiu Feng-fang;Ma Jing-e;Zhang De-xiang;Nie Qing-hua;Zhang Xi-quan
关键词:natural antisense transcripts;transcription orientation;detection method;RNA sequencing;long non-coding RNA
-
Determination of Residual Feed Intake and Its Associations with Single Nucleotide Polymorphism in Chickens
作者:Xu Zhen-qiang;Chen Jie;Zhang De-xiang;Zhang Xi-quan;Zhang Yan;Ji Cong-liang
关键词:RFI;model;SNPs;growth traits;association
-
Characterization of MicroRNA* Species in Peking Duck Skin
作者:Zhang Li;Xiao Mei;An Li-long;Xie Xiu-juan;Lin Shu-dai;Luo Wen;Jia Xin-zheng;Nie Qing-hua;Zhang Xi-quan;Jia Shan-gang
关键词:Peking duck;miRNA star species (miRNA*);skin;nucleotide bias
-
The Effects of Different Sex-Linked Dwarf Variations on Chinese Native Chickens
作者:Ouyang Jian-hua;Xie Liang;Nie Qing-hua;Zeng Hua;Zhang De-xiang;Zhang Xi-quan;Ouyang Jian-hua;Ouyang Jian-hua;Peng Zhi-jun;Zhang De-xiang;Xie Liang
关键词:SLD chicken;GHR;dwarf allele;phenotypic effect