Myomaker, Regulated by MYOD, MYOG and miR-140-3p, Promotes Chicken Myoblast Fusion

文献类型： 外文期刊

第一作者： Luo, Wen

作者： Luo, Wen;Li, Erxin;Nie, Qinghua;Zhang, Xiquan;Luo, Wen;Li, Erxin;Nie, Qinghua;Zhang, Xiquan;Luo, Wen;Li, Erxin;Nie, Qinghua;Zhang, Xiquan

作者机构：

关键词： chicken;Myomaker;myoblast fusion;MYOD;MYOG;miR-140-3p

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1422-0067

年卷期： 2015 年 16 卷 11 期

页码：

收录情况： SCI

摘要： The fusion of myoblasts is an important step during skeletal muscle differentiation. A recent study in mice found that a transmembrane protein called Myomaker, which is specifically expressed in muscle, is critical for myoblast fusion. However, the cellular mechanism of its roles and the regulatory mechanism of its expression remain unclear. Chicken not only plays an important role in meat production but is also an ideal model organism for muscle development research. Here, we report that Myomaker is also essential for chicken myoblast fusion. Forced expression of Myomaker in chicken primary myoblasts promotes myoblast fusion, whereas knockdown of Myomaker by siRNA inhibits myoblast fusion. MYOD and MYOG, which belong to the family of myogenic regulatory factors, can bind to a conserved E-box located proximal to the Myomaker transcription start site and induce Myomaker transcription. Additionally, miR-140-3p can inhibit Myomaker expression and myoblast fusion, at least in part, by binding to the 3' UTR of Myomaker in vitro. These findings confirm the essential roles of Myomaker in avian myoblast fusion and show that MYOD, MYOG and miR-140-3p can regulate Myomaker expression.

分类号：

  • 相关文献

[1]Myf5 and MyoG gene SNPs associated with Bian chicken growth trait. Wei, Y.,Zhang, G. X.,Zhang, T.,Wang, J. Y.,Fan, Q. C.,Tang, Y.,Wei, Y.,Zhang, G. X.,Zhang, T.,Wang, J. Y.,Fan, Q. C.,Tang, Y.,Wei, Y.,Ding, F. X.,Zhang, L.. 2016

[2]Cloning and expression of MyoG gene from Hu sheep and identification of its myogenic specificity. Zhang, Zhentao,Xu, Feng,Zhang, Yani,Li, Wei,Yin, Yanhui,Zhu, Caiye,Elsayed, A. K.,Li, Bichun,Du, Lixin,Elsayed, A. K..

[3]Characterization of miR-206 Promoter and Its Association with Birthweight in Chicken. Jia, Xinzheng,Lin, Huiran,Abdalla, Bahareldin Ali,Nie, Qinghua,Jia, Xinzheng,Lin, Huiran,Abdalla, Bahareldin Ali,Nie, Qinghua,Jia, Xinzheng,Lin, Huiran,Abdalla, Bahareldin Ali,Nie, Qinghua. 2016

[4]Molecular characterization, expression pattern, and association analysis with carcass traits of the porcine SHIP2 gene. Xiong, Qi,Li, Xiaofeng,Suo, Xiaojun,Zhang, Nian,Yang, Qianping,Liu, Yang,Chen, Mingxin,Chai, Jin,Deng, Changyan,Jiang, Siwen,Zheng, Rong,Chai, Jin,Deng, Changyan,Jiang, Siwen,Zheng, Rong. 2012

[5]Effects of fasting and refeeding on expression of MAFbx and MuRF1 in chick skeletal muscle. Li QingHe,Li JinXiu,Lan He,Hu XiaoXiang,Li Ning,Wang Nan,Chen Li. 2011

[6]Molecular cloning and characterization of the Myf5 gene in sea perch (Lateolabrax japonicus). Ye, Han-Qing,Chen, Song-Lin,Xu, Jian-Yong.

[7]Deep Sequencing Analysis of miRNA Expression in Breast Muscle of Fast-Growing and Slow-Growing Broilers. Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan,Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan,Ouyang, Hongjia,He, Xiaomei,Li, Guihuan,Xu, Haiping,Jia, Xinzheng,Nie, Qinghua,Zhang, Xiquan. 2015

[8]Molecular epidemiology of hydropericardium syndrome outbreak-associated serotype 4 fowl adenovirus isolates in central China. Zhang, Teng,Zhang, Teng,Jin, Qianyue,Ding, Peiyang,Chai, Yongxiao,Li, Yafei,Liu, Xiao,Luo, Jun,Zhang, Gaiping,Chai, Yongxiao,Liu, Xiao,Zhang, Gaiping,Ding, Peiyang,Li, Yafei,Wang, Yinbiao,Jin, Qianyue,Zhang, Gaiping. 2016

[9]A premature stop codon within the tvb receptor gene results in decreased susceptibility to infection by avian leukosis virus subgroups B, D, and E. Chen, WeiGuo,Liu, Yang,Li, Xinjian,Li, Hongxing,Dai, Zhenkai,Yan, Yiming,Zhang, Xinheng,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei,Chen, WeiGuo,Liu, Yang,Li, Xinjian,Li, Hongxing,Dai, Zhenkai,Yan, Yiming,Zhang, Xinheng,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei,Li, Aijun,Shu, Dingming,Zhang, Huanmin,Chen, WeiGuo,Liu, Yang,Li, Xinjian,Li, Hongxing,Dai, Zhenkai,Yan, Yiming,Zhang, Xinheng,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei,Chen, WeiGuo,Lin, Wencheng,Ma, Jingyun,Xie, Qingmei. 2017

[10]Differential expression of L-FABP and L-BABP between fat and lean chickens. Zhang, Q.,Shi, H.,Liu, W.,Wang, Y.,Wang, Q.,Li, H.,Zhang, Q.,Shi, H.,Liu, W.,Wang, Y.,Li, H.,Wang, Q.. 2013

[11]An association between genetic variation in the roundabout, axon guidance receptor, homolog 2 gene and immunity traits in chickens. Shu, D. M.. 2014

[12]Differentially expressed genes in the liver of lean and fat chickens. He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Wang, Q. G.,Li, H.,He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Wang, Q. G.,Li, H.,He, Q.,Wang, S. Z.,Leng, L.,Na, W.,Li, H.,Wang, Q. G.. 2014

[13]A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken. Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming,Hu, Xiaoxiang,Li, Ning,Luo, Chenglong,Qu, Hao,Ma, Jie,Wang, Jie,Shu, Dingming. 2014

[14]Biological Characteristics of Chinese Precocious Strain of Eimeria acervulina and Its Immune Efficacy Against Different Field Strains. Wu, Lin-Lin,Lin, Rui-Qing,Duan, Wen-Fang,Zou, Shang-Shu,Yuan, Zi-Guo,Weng, Ya-Biao,Sun, Ming-Fei,Liu, Li-Dan. 2014

[15]Determination of virginiamycin M1 residue in tissues of swine and chicken by ultra-performance liquid chromatography tandem mass spectrometry. Wang, Xiaoyang,Wang, Mi,Zhang, Keyu,Hou, Ting,Zhang, Lifang,Fei, Chenzong,Xue, Feiqun,Wang, Xiaoyang,Hang, Taijun. 2018

[16]Up-regulation of NLRC5 and NF-kappa B signaling pathway in carrier chickens challenged with Salmonella enterica Serovar Pullorum at different persistence periods. Liu, Xiangping,Sheng, Zhongwei,Dou, Xinhong,Wang, Kehua,Ma, Teng,Wang, Hongzhi,Li, Zhiteng,Pan, Zhiming,Chang, Guobin,Chen, Guohong. 2015

[17]Dissection of Myogenic Differentiation Signatures in Chickens by RNA-Seq Analysis. Li, Tingting,Zhang, Genxi,Wu, Pengfei,Liu, Qiuhong,Wang, Jinyu,Duan, Lian,Li, Guohui. 2018

[18]Combination of multi-element and stable isotope analysis improved the traceability of chicken from four provinces of China. Zhao, Yan,Wang, Donghua,Yang, Shuming,Zhao, Yan,Wang, Donghua,Yang, Shuming,Zhang, Bin,Guo, Bin,Guo, Bin. 2016

[19]Complete mitochondrial genome sequence and gene organization of Chinese indigenous chickens with phylogenetic considerations. Zhao, F. P.,Zhang, B. K.,Zhao, F. P.,Fan, H. Y.,Fan, H. Y.,Li, G. H.. 2016

[20]Detecting Splicing Variants of FOXP2 and its Protein Expression in Chicken Brain. Wang, Xi,Hamid, Mohammod Abdul,Zhao, Xingbo,Wang, Xi,Li, Hongxia. 2012

作者其他论文 更多>>

微信小程序