The multi-herbal formula Chong-Myung-Tang improves spatial memory and increases cell genesis in the dentate gyrus of aged mice

文献类型: 外文期刊

第一作者: Liu, Lei

作者: Liu, Lei;Zhang, Mingwei;Zhang, Ruifen;Lee, Mira;Hou, Jingang;Sung, Chang-Keun;Wang, Zhen

作者机构:

关键词: dentate gyrus;cell proliferation;cell survival;spatial memory;Chong-Myung-Tang

期刊名称:BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY ( 影响因子:2.043; 五年影响因子:2.017 )

ISSN: 0916-8451

年卷期: 2014 年 78 卷 10 期

页码:

收录情况: SCI

摘要: Chong-Myung-Tang (CMT) is a multi-herbal formula that has been used to improve memory. However, the potential mechanism remains unknown. The present study investigated the effects of CMT (50, 100, and 200 mg/kg) on spatial memory of aged mice. The behavioral training tests indicated that 200 mg/kg CMT treatment can significantly improve spatial memory of aged mice in the Morris water maze. Moreover, cell survival was examined by injecting bromodeoxyuridine (BrdU) on the first three days. The result showed that 200 mg/kg CMT treatment significantly increased cell survival in the dentate gyrus. Cell proliferation was determined by injecting BrdU 2 h before the mice were killed. The result suggested that CMT treatments had no influence on cell proliferation in the dentate gyrus. Thus, an increase in cell survival in the dentate gyrus stimulated by CMT may be involved in the effect of CMT on spatial memory improvement.

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