Hyperoside Downregulates the Receptor for Advanced Glycation End Products (RAGE) and Promotes Proliferation in ECV304 Cells via the c-Jun N-Terminal Kinases (JNK) Pathway Following Stimulation by Advanced Glycation End-Products In Vitro

文献类型： 外文期刊

第一作者： Zhang, Zhengyu

作者： Zhang, Zhengyu;Shen, Weizhi;Liao, Sentai;Zou, Yuxiao;Zhang, Zhengyu;Sethiel, Mosha Silas

作者机构：

关键词： hyperoside;RAGE;AGE;JNK;ECV304

期刊名称：INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES （ 影响因子：5.923； 五年影响因子：6.132 ）

ISSN： 1422-0067

年卷期： 2013 年 14 卷 11 期

页码：

收录情况： SCI

摘要： Hyperoside is a major active constituent in many medicinal plants which are traditionally used in Chinese medicines for their neuroprotective, anti-inflammatory and antioxidative effects. The molecular mechanisms underlying these effects are unknown. In this study, quiescent ECV304 cells were treated in vitro with advanced glycation end products (AGEs) in the presence or absence of hyperoside. The results demonstrated that AGEs induced c-Jun N-terminal kinases (JNK) activation and apoptosis in ECV304 cells. Hyperoside inhibited these effects and promoted ECV304 cell proliferation. Furthermore, hyperoside significantly inhibited RAGE expression in AGE-stimulated ECV304 cells, whereas knockdown of RAGE inhibited AGE-induced JNK activation. These results suggested that AGEs may promote JNK activation, leading to viability inhibition of ECV304 cells via the RAGE signaling pathway. These effects could be inhibited by hyperoside. Our findings suggest a novel role for hyperoside in the treatment and prevention of diabetes.

分类号：

  • 相关文献

[1]Effect of parasitism on flight behavior of the soybean aphid, Aphis glycines. Wu, Kongming,Wyckhuys, Kris A. G.,Heimpel, George E..

[2]Identification and characterization of a novel adenine phosphoribosyltransferase gene (ZmAPT2) from maize (Zea mays L.). Wu, Suowei,Yu, Zhanwang,Li, Weihua,Yang, Qingkai,Ye, Chunjiang,Sun, Yan,Jin, Demin,Wang, Bin,Wu, Suowei,Li, Weihua,Yang, Qingkai,Wang, Fengge,Zhao, Jiuran.

[3]Separation of flavonol glycosides from Flaveria bidentis (L.) Kuntze by high-speed counter-current chromatography. Xie, Qianqian,Wei, Yun,Zhang, Guoliang.

[4]Regulation of Stress Responses and Translational Control by Coronavirus. Fung, To Sing,Liu, Ding Xiang,Liao, Ying. 2016

[5]D-chiro-inositol enriched Fagopyrum tataricum (L.) Gaench extract alleviates mitochondria' malfunction and inhibits ER stress/JNK associated inflammation in the endothelium. Zhang, Bobo,Gao, Caifeng,Wang, Min,Li, Yunlong. 2018

[6]First report of the molecular detection of Ancylostoma caninum in Lahore, Pakistan: the threat from pets. Rehman, A.,Shehzad, W.,Islam, S.,Bajwa, A. A.,Akhtar, R.,Rashid, I.,Akbar, H.,Riaz, F.,Waqas, M.. 2017

[7]Effects of constant temperature, exposure period, and age on diapause induction in Trichogramma dendrolimi. Ma, CS,Chen, YW. 2006

[8]Estimation of the Age and Amount of Brown Rice Plant Hoppers Based on Bionic Electronic Nose Use. Xu, Sai,Zhou, Zhiyan,Lu, Huazhong,Luo, Xiwen,Lan, Yubin,Xu, Sai,Zhou, Zhiyan,Lu, Huazhong,Luo, Xiwen,Lan, Yubin,Lan, Yubin,Zhang, Yang,Li, Yanfang,Zhang, Yang,Li, Yanfang. 2014

[9]Comparative flight performance of three important pest Adelphocoris species of Bt cotton in China. Wu, K. M.,Guo, Y. Y.,Wyckhuys, K. A. G..

[10]Estimation of age, growth and maturation of purpleback flying squid, Sthenoteuthis oualaniensis, in Bashi Channel, central Pacific Ocean. Liu, Bilin,Lin, Jingyuan,Li, Jianhua,Su, Hang,Feng, Chunlei. 2017

[11]AGE PREFERENCE AND FITNESS OF MICROPLITIS MANILAE (HYMENOPTERA: BRACONIDAE) REARED ON SPODOPTERA EXIGUA (LEPIDOPTERA: NOCTUIDAE). Xu, Zaifu,Qiu, Bo,Zhou, Zhongshi. 2013

[12]Effects of morphological traits, age and copulation experience on mate choice in Ophraella communa. Guo, Jian-Ying,Guo, Wei,Zheng, Hai-Yan,Wan, Fang-Hao,Guo, Wei,Zheng, Hai-Yan. 2012

[13]Experimental infection of duck origin virulent Newcastle disease virus strain in ducks. Dai, Yabin,Cheng, Xu,Liu, Mei,Shen, Xinyue,Li, Jianmei,Zou, Jianmin,Dai, Yabin,Cheng, Xu,Liu, Mei,Shen, Xinyue,Li, Jianmei,Zou, Jianmin,Yu, Shengqing,Ding, Chan. 2014

[14]Age- and sex-associated differences in the glycopatterns of human salivary glycoproteins and their roles against influenza A virus. Qin, Yannan,Zhong, Yaogang,Zhu, Minzhi,Dang, Liuyi,Yu, Hanjie,Chen, Zhuo,Chen, Wentian,Li, Zheng,Wang, Xiurong,Zhang, Hua.

[15]Development Rule of Intramuscular Fat Content in Chicken. Chang Guo-Bin,Lei Li-Li,Chen Rong,Luan De-Qin,Chen Guo-Hong,Zhang Xue-Yu,Wang Ke-Hua,Wang Ke-Hua. 2010

[16]Molecular Characterization and Expression Pattern of Two General Odorant Binding Proteins from the Diamondback Moth, Plutella xylostella. Zhang, Zhi-Chun,Wang, Man-Qun,Zhang, Guoan,Lu, Yao-Bin.

[17]Seroprevalence of Q fever in dairy cows in northeastern China. Ni, Hong-Bo,Qian, Ai-Dong,Ni, Hong-Bo,Jiang, Hai-Fang,Wang, Chun-Ren,Liu, Si-Guo. 2011

[18]Determination and consideration of flight potential in a laboratory population of true armyworm (Lepidoptera : Noctuidae). Luo, LZ,Johnson, SJ,Hammond, AM,Lopez, JD,Geaghan, JP,Beerwinkle, KR,Westbrook, JK. 2002

作者其他论文 更多>>

微信小程序