Genetic effects of polymorphisms in candidate genes and the QTL region on chicken age at first egg
文献类型： 外文期刊
第一作者： Xu, Haiping
作者： Xu, Haiping;Zeng, Hua;Zhang, Dexiang;Wang, Qian;Sun, Liang;Yang, Lishan;Nie, Qinghua;Zhang, Xiquan;Luo, Chenglong;Zhou, Min
作者机构：
期刊名称：BMC GENETICS （ 影响因子：2.797； 五年影响因子：3.263 ）
ISSN： 1471-2156
年卷期： 2011 年 12 卷
页码：
收录情况： SCI
摘要： Background: The age at first egg (AFE), an important indicator for sexual maturation in female chickens, is controlled by polygenes. Based on our knowledge of reproductive physiology, 6 genes including gonadotrophin releasing hormone-I (GnRH-I), neuropeptide Y (NPY), dopamine D2 receptor (DRD2), vasoactive intestinal polypeptide (VIP), VIP receptor-1 (VIPR-1), and prolactin (PRL), were selected as candidates for influencing AFE. Additionally, the region between ADL0201 and MCW0241 of chromosome Z was chosen as the candidate QTL region according to some QTL databases. The objective of the present study was to investigate the effects of mutations in candidate genes and the QTL region on chicken AFE. Results: Marker-trait association analysis of 8 mutations in those 6 genes in a Chinese native population found a highly significant association (P < 0.01) between G840327C of the GnRH-I gene with AFE, and it remained significant even with Bonferroni correction. Based on the results of the 2-tailed chi(2) test, mutations T32742394C, T32742468C, G32742603A, and C33379782T in the candidate QTL region of chromosome Z were selected for marker-trait association analysis. The haplotypes of T32742394C and T32742468C were significantly associated (P < 0.05) with AFE. Bioinformatics analysis indicated that T32742394C and T32742468C were located in the intron region of the SH3-domain GRB2-like 2 (SH3GL2) gene, which appeared to be associated in the endocytosis and development of the oocyte. Conclusion: This study found that G840327C of the GnRH-I gene and the haplotypes of T32742394C-T32742468C of the SH3GL2 gene were associated with the chicken AFE.
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