Antibiotic accumulation, growth performance, intestinal diversification, and function of Nile tilapia (Oreochromis niloticus) feed by diets supplemented with different doses of sulfamethoxazole

文献类型： 外文期刊

第一作者： Fang, Longxiang

作者： Fang, Longxiang;Chen, Xi;Qiu, Liping;Fan, Limin;Meng, Shunlong;Song, Chao;Fang, Longxiang;Qiu, Liping;Fan, Limin;Meng, Shunlong;Song, Chao;Fang, Longxiang;Qiu, Liping;Fan, Limin;Meng, Shunlong;Song, Chao;Chen, Xi;Shan, Xiangbao;Fan, Limin;Meng, Shunlong;Song, Chao

作者机构：

关键词： Sulfamethoxazole; Nile tilapia; Antibiotic accumulation; Growth performance; Intestinal diversification and function

期刊名称：ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH （ 影响因子：4.223； 五年影响因子：4.306 ）

ISSN： 0944-1344

年卷期： 2021 年 28 卷 46 期

页码：

收录情况： SCI

摘要： To comprehensively investigate the effects of exposure to legal doses of sulfamethoxazole (SMZ) in Nile tilapia (Oreochromis niloticus), fishes were exposed to diets supplemented with different doses of SMZ (NS, normal feed; LS, 20 mg/kg center dot day; MS, 200 mg/kg center dot day; and HS, 1000 mg/kg center dot day) for 4 weeks and then fed with normal feed for 4 weeks. General SMZ accumulation, growth performance, intestinal short-chain fatty acids, intestinal flora diversity, composition, and function were systemically evaluated. Results indicated that the SMZ accumulation in O. niloticus muscles, intestinal contents, and aquaculture environment positively correlated to the exposure dose. The growth performance, measured by weight increase, was MS>LS>NS, while HS antibiotics retarded the growth. SMZ-exposed O. niloticus had an increased number of fat particles in the liver and a change in the content of intestinal SCFAs. Moreover, SMZ exposure changed the biological diversity of the intestinal flora and subsequently induced microbiota dysbiosis, primarily inhibiting the growth of Fusobacteria, especially in HS group. Overall, exposure to higher SMZ doses than the recommended ones impair general intestinal functions and provokes health risk in fish. This study highlights the importance of rational and regulated use of SMZ in aquaculture.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序