A genome-wide association study identifies a genomic region for the polycerate phenotype in sheep (Ovis aries)

文献类型： 外文期刊

第一作者： Ren, Xue

作者： Ren, Xue;Yang, Guang-Li;Peng, Wei-Feng;Zhao, Yong-Xin;Zhang, Min;Chen, Ze-Hui;Li, Meng-Hua;Ren, Xue;Peng, Wei-Feng;Zhao, Yong-Xin;Chen, Ze-Hui;Yang, Guang-Li;Wu, Fu-An;Kantanen, Juha;Kantanen, Juha;Shen, Min;Shen, Min

作者机构：

期刊名称：SCIENTIFIC REPORTS （ 影响因子：4.379； 五年影响因子：5.133 ）

ISSN： 2045-2322

年卷期： 2016 年 6 卷

页码：

收录情况： SCI

摘要： Horns are a cranial appendage found exclusively in Bovidae, and play important roles in accessing resources and mates. In sheep (Ovies aries), horns vary from polled to six-horned, and human have been selecting polled animals in farming and breeding. Here, we conducted a genome-wide association study on 24 two-horned versus 22 four-horned phenotypes in a native Chinese breed of Sishui Fur sheep. Together with linkage disequilibrium (LD) analyses and haplotype-based association tests, we identified a genomic region comprising 132.0-133.1 Mb on chromosome 2 that contained the top 10 SNPs (including 4 significant SNPs) and 5 most significant haplotypes associated with the polycerate phenotype. In humans and mice, this genomic region contains the HOXD gene cluster and adjacent functional genes EVX2 and KIAA1715, which have a close association with the formation of limbs and genital buds. Our results provide new insights into the genetic basis underlying variable numbers of horns and represent a new resource for use in sheep genetics and breeding.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序