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The advancements, challenges, and future implications of the CRISPR/Cas9 system in swine research

文献类型：外文期刊

第一作者： Zhang, Jinfu

作者： Zhang, Jinfu;Zhou, Yuan;Nie, Xiongwei;Ruan, Jinxue;Zhao, Changzhi;Xu, Jing;Li, Xinyun;Zhao, Shuhong;Xie, Shengsong;Zhang, Jinfu;Zhou, Yuan;Nie, Xiongwei;Ruan, Jinxue;Zhao, Changzhi;Xu, Jing;Li, Xinyun;Zhao, Shuhong;Xie, Shengsong;Khazalwa, Emmanuel M.;Abkallo, Hussein M.;Steinaa, Lucilla;Xie, Shengsong;Wang, Jieru;Li, Xinyun;Zhao, Shuhong;Xie, Shengsong;Zuo, Erwei

作者机构：

关键词： CRISPR/Cas9; Swine; Genome editing; CRISPR screening; Base editing

期刊名称：JOURNAL OF GENETICS AND GENOMICS （影响因子：4.275；五年影响因子：5.223 ）

ISSN： 1673-8527

年卷期： 2021 年 48 卷 5 期

页码：

收录情况： SCI

摘要： Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) genome editing technology has dramatically influenced swine research by enabling the production of high-quality disease-resistant pig breeds, thus improving yields. In addition, CRISPR/Cas9 has been used extensively in pigs as one of the tools in biomedical research. In this review, we present the advancements of the CRISPR/Cas9 system in swine research, such as animal breeding, vaccine development, xenotransplantation, and disease modeling. We also highlight the current challenges and some potential applications of the CRISPR/Cas9 technologies. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.

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