The advancements, challenges, and future implications of the CRISPR/Cas9 system in swine research

文献类型： 外文期刊

第一作者： Zhang, Jinfu

作者： Zhang, Jinfu;Zhou, Yuan;Nie, Xiongwei;Ruan, Jinxue;Zhao, Changzhi;Xu, Jing;Li, Xinyun;Zhao, Shuhong;Xie, Shengsong;Zhang, Jinfu;Zhou, Yuan;Nie, Xiongwei;Ruan, Jinxue;Zhao, Changzhi;Xu, Jing;Li, Xinyun;Zhao, Shuhong;Xie, Shengsong;Khazalwa, Emmanuel M.;Abkallo, Hussein M.;Steinaa, Lucilla;Xie, Shengsong;Wang, Jieru;Li, Xinyun;Zhao, Shuhong;Xie, Shengsong;Zuo, Erwei

作者机构：

关键词： CRISPR/Cas9; Swine; Genome editing; CRISPR screening; Base editing

期刊名称：JOURNAL OF GENETICS AND GENOMICS （ 影响因子：4.275； 五年影响因子：5.223 ）

ISSN： 1673-8527

年卷期： 2021 年 48 卷 5 期

页码：

收录情况： SCI

摘要： Clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (CRISPR/Cas9) genome editing technology has dramatically influenced swine research by enabling the production of high-quality disease-resistant pig breeds, thus improving yields. In addition, CRISPR/Cas9 has been used extensively in pigs as one of the tools in biomedical research. In this review, we present the advancements of the CRISPR/Cas9 system in swine research, such as animal breeding, vaccine development, xenotransplantation, and disease modeling. We also highlight the current challenges and some potential applications of the CRISPR/Cas9 technologies. Copyright (C) 2021, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, and Genetics Society of China. Published by Elsevier Limited and Science Press. All rights reserved.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序