Antiviral and immunoregulatory role against PCV2 in vivo of Chinese herbal medicinal ingredients

文献类型： 外文期刊

第一作者： Yang, Haifeng

作者： Yang, Haifeng;Chen, Xiaolan;Jiang, Chunmao;He, Kongwang;Hu, Yiyi;He, Kongwang;Hu, Yiyi

作者机构：

关键词： porcine circovirus;saponins;antivirus properties;immune system

期刊名称：JOURNAL OF VETERINARY RESEARCH （ 影响因子：1.744； 五年影响因子：1.838 ）

ISSN： 2450-7393

年卷期： 2017 年 61 卷 4 期

页码：

收录情况： SCI

摘要： Introduction: The aim of the research was to investigate the antiviral and immunoregulatory effects of saikosaponin A, saikosaponin D, Panax notoginseng saponins, notoginsenoside R1, and anemoside B4 saponins commonly found in Chinese herbal medicines. Material and Methods: control mice were challenged intramuscularly (im) with 0.2 mL of porcine circovirus 2 (PCV2) solution containing 10(7) TCID50 of the virus/mL. Mice of high-, middle-, and low-dose saponin groups were initially challenged im with 0.2 mL of PCV2 solution and three days later treated intraperitoneally (ip) with one of five saponins at one of three doses (10, 5, or 1 mg/kg b.w.). In the drug control group, mice were dosed ip with 10 mg/kg b.w. of a given saponin, and mice in a blank control group were administered the same volume of normal saline. Results: The results revealed that the saponins could reduce the incidence and severity of PCV2-induced immunopathological damage, e.g. body temperature elevation, weight loss, anaemia, and internal organ swelling. In addition, it was seen that the saponins could affect the immunoglobulin levels and protein absorption. Conclusion: The data suggested that the saponins might effectively regulate immune responses.

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