Characterization of roles of SpaA in Erysipelothrix rhusiopathiae adhesion to porcine endothelial cells

文献类型： 外文期刊

第一作者： Zhu, Weifeng

作者： Zhu, Weifeng;Cai, Chengzhi;Wang, Ya;Li, Jingtao;Kang, Chao;Sun, Xiaomei;Jin, Meilin;Zhu, Weifeng;Cai, Chengzhi;Wang, Ya;Li, Jingtao;Kang, Chao;Sun, Xiaomei;Jin, Meilin;Wu, Chao;Sun, Xiaomei;Jin, Meilin;Wu, Chao;Sun, Xiaomei;Jin, Meilin;Zhu, Weifeng

作者机构：

关键词： Adhesin;Endothelial cell;Fibronectin;Plasminogen;Virulence factor

期刊名称：MICROBIAL PATHOGENESIS （ 影响因子：3.738； 五年影响因子：3.663 ）

ISSN： 0882-4010

年卷期： 2017 年 113 卷

页码：

收录情况： SCI

摘要： Erysipelothrix rhusiopathiae is the causative agent of animal erysipelas and human erysipeloid. The major protective antigen SpaA was suggested to play important roles in E. rhusiopathiae adhesion to host cells, but there is no specific study on SpaA pathogenic roles in adhesion. In this study we characterized direct and indirect roles of SpaA in E. rhusiopathiae adhesion to porcine endothelial cells. Recombinant E. rhusiopathiae SpaA (rSpaA) successfully binded to porcine iliac arterial endothelial cells. rSpaA protein pre-incubating endothelial cells or rSpaA antiserum pre-incubating E. rhusiopathiae significantly decreased E. rhusiopathiae adhesion to endothelial cells. rSpaA successfully binded host plasminogen and fibronectin, and rSpaA antiserum significantly decreased plasminogen-recruitment activity but not fibronectin-recruitment activity of E. rhusiopathiae. In conclusion, SpaA acts as adhesin in E. rhusiopathiae adhesion to host cells, and SpaA binding activity to host plasminogen highly likely play roles in this adhesion.

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