Single Dose of Consensus Hemagglutinin-Based Virus-Like Particles Vaccine Protects Chickens against Divergent H5 Subtype Influenza Viruses

文献类型: 外文期刊

第一作者: Wu, Peipei

作者: Wu, Peipei;Lu, Jihu;Zhang, Xuehua;Mei, Mei;Feng, Lei;Hou, Jibo;Tang, Yinghua;Wu, Peipei;Lu, Jihu;Zhang, Xuehua;Mei, Mei;Feng, Lei;Hou, Jibo;Tang, Yinghua;Wu, Peipei;Lu, Jihu;Zhang, Xuehua;Mei, Mei;Feng, Lei;Peng, Daxin;Hou, Jibo;Liu, Xiufan;Tang, Yinghua;Peng, Daxin;Liu, Xiufan;Kang, Sang-Moo

作者机构:

关键词: H5 subtype influenza virus;vaccine;consensus;virus-like particles;broad protection

期刊名称:FRONTIERS IN IMMUNOLOGY ( 影响因子:7.561; 五年影响因子:7.624 )

ISSN: 1664-3224

年卷期: 2017 年 8 卷

页码:

收录情况: SCI

摘要: The H5 subtype highly pathogenic avian influenza (HPAI) virus is one of the greatest threats to global poultry industry. To develop broadly protective H5 subunit vaccine, a recombinant consensus HA sequence (rHA) was constructed and expressed in virus-like particles (rHA VLPs) in the baculovirus-insect cell system. The efficacy of the rHA VLPs vaccine with or without immunopotentiator (CVCVA5) was assessed in chickens. Compared to the commercial Re6 or Re6-CVCVA5 vaccines, single dose immunization of chickens with rHA VLPs or rHA-CVCVA5 vaccines induced higher levels of serum hemagglutinin inhibition titers and neutralization titers, mucosal antibodies, IFN-gamma and IL-4 cytokines in sera, and cytotoxic T lymphocyte responses. The rHA VLPs vaccine was superior to the commercial Re6 vaccine in conferring cross-protection against different clades of H5 subtype viruses. This study reports that H5 subtype consensus HA VLP single dose vaccination provides broad protection against HPAI virus in chickens.

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