Microplastics interact with SARS-CoV-2 and facilitate host cell infection

文献类型： 外文期刊

第一作者： Zhang, Guofang

作者： Zhang, Guofang;Cao, Guoli;Song, Qingle;Zeng, Yanqiao;Boraschi, Diana;Li, Yang;Zhang, Guofang;Cao, Guoli;Song, Qingle;Zeng, Yanqiao;Boraschi, Diana;Li, Yang;Cao, Guoli;Chang, Yan-Zhong;Luo, Rong-Hua;Liu, Feng-Liang;Zheng, Yong-Tang;Liu, Ke;Lin, Xian;Li, Hongchang;Qu, Jing;Li, Liang;Wang, Guocheng;Wu, Lidong

作者机构：

期刊名称：ENVIRONMENTAL SCIENCE-NANO （ 影响因子：9.473； 五年影响因子：9.35 ）

ISSN： 2051-8153

年卷期： 2022 年 9 卷 8 期

页码：

收录情况： SCI

摘要： Microplastics (MP) pollution is a global issue that raises concerns about potential toxicity for environmental and human health. The notion that SARS-CoV-2 is more stable when adsorbed on plastic surfaces urged us to examine whether the virus can attach to MP, which may facilitate infection upon inhalation or ingestion. Here, we describe that MP can bind SARS-CoV-2 pseudovirus on their surface and enhance infection of human cells in vitro. This enhanced in vitro infectivity was confirmed with authentic SARS-CoV-2, in parallel with increased expression of inflammation-related caspase-3, IL-8 and TNF-alpha genes. These results suggest that the presence of MP in the environment or in our respiratory or gastrointestinal tracts has the potential to interact with SARS-CoV-2, and potentially increase viral infectivity and spreading.

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