Highly Sensitive and Selective DNA-Based Detection of Mercury(II) with alpha-Hemolysin Nanopore

文献类型： 外文期刊

第一作者： Wen, Shuang

作者： Wen, Shuang;Liu, Lei;Zhao, Kai;Zhao, Yuliang;Wu, Hai-Chen;Zeng, Tao;Zhao, Yuliang;Liu, Xianjin

作者机构：

期刊名称：JOURNAL OF THE AMERICAN CHEMICAL SOCIETY （ 影响因子：15.419； 五年影响因子：15.801 ）

ISSN： 0002-7863

年卷期： 2011 年 133 卷 45 期

页码：

收录情况： SCI

摘要： The duplex formation mediated by Hg(2+) in a properly designed ssDNA generates a stable hairpin structure, which greatly alters the translocation profile of the ssDNA through a-hemolysin nanopore. From the 2D-events contour plot, the presence of Hg(2+) can be confirmed in as little as 30 min at similar to 7 nM or higher. The sensor is highly selective to Hg(2+), without interference from other metal ions. It can be fabricated from readily available materials, without the processes of synthesis, purification, probe-making, and so forth. This sensing strategy opens new possibilities for detecting many types of analytes which have specific interactions with DNA molecules.

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