Sensitive and selective nanoplasmonic sensor by functionalized nanoporous gold nanoparticle array chip

文献类型: 外文期刊

第一作者: Zhao, Fusheng

作者: Zhao, Fusheng;Qiu, Suyan;Li, Jingting;Shih, Wei-Chuan;Shih, Wei-Chuan;Shih, Wei-Chuan;Shih, Wei-Chuan;Qiu, Suyan

作者机构:

关键词: NPG-NP array chip;Guanine-quadruplex (G4);Malachite green

期刊名称:PLASMONICS IN BIOLOGY AND MEDICINE XIV

ISSN: 0277-786X

年卷期: 2017 年 10080 卷

页码:

收录情况: SCI

摘要: Nanoplasmonic sensor has become a recent research focus due to its significant signal enhancement and robust signal transduction measured by various techniques. However, since the native gold surface does not have the capability to selectively bind target biomolecules, high molecular specificity has been a challenge. Nanoporous gold nanoparticle (NPG-NP) array chip showcases large specific surface area and high-density plasmonic field enhancement known as "hot-spots". In this paper, we discuss strategies to enhance molecular specificity by functionalizing NPG-NP with unique bio-recognition elements towards both high sensitivity and specificity. A few examples will be given using existing and novel bio-recognition elements.

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