Dietary wolfberry upregulates carotenoid metabolic genes and enhances mitochondrial biogenesis in the retina of db/db diabetic mice

文献类型： 外文期刊

第一作者： Yu, Huifeng

作者： Yu, Huifeng;Wark, Logan;Ji, Hua;Jaing, Yu;Han, Jing;Ortiz, Edlin;Zhang, Yunong;Medeiros, Denis M.;Lin, Dingbo;Ji, Hua;He, Hui;Willard, Lloyd;Medeiros, Denis M.

作者机构：

关键词： Carotenoids;Diabetic retinopathy;Hypoxia;Mitochondrial biogenesis;Wolfberry

期刊名称：MOLECULAR NUTRITION & FOOD RESEARCH （ 影响因子：5.914； 五年影响因子：6.409 ）

ISSN： 1613-4125

年卷期： 2013 年 57 卷 7 期

页码：

收录情况： SCI

摘要： Scope: Our aim was to investigate whether dietary wolfberry altered carotenoid metabolic gene expression and enhanced mitochondrial biogenesis in the retina of diabetic mice. Methods and results: Six-week-old male db/db and wild-type mice were fed the control or wolfberry diets for 8 weeks. At study termination, liver and retinal tissues were collected for analysis by transmission electron microscopy, real-time PCR, immunoprecipitation, Western blot, and HPLC. Wolfberry elevated zeaxanthin and lutein levels in the liver and retinal tissues and stimulated expression of retinal scavenger receptor class B type I, glutathione S-transferase Pi 1, and ,-carotene 9,10-oxygenase 2, and induced activation and nuclear enrichment of retinal AMP-activated protein kinase 2 (AMPK-2). Furthermore, wolfberry attenuated hypoxia and mitochondrial stress as demonstrated by declined expression of hypoxia-inducible factor-1-, vascular endothelial growth factor, and heat shock protein 60. Wolfberry enhanced retinal mitochondrial biogenesis in diabetic retinas as demonstrated by reversed mitochondrial dispersion in the retinal pigment epithelium, increased mitochondrial copy number, elevated citrate synthase activity, and upregulated expression of peroxisome proliferator-activated receptor co-activator 1, nuclear respiratory factor 1, and mitochondrial transcription factorA. Conclusion: Consumption of dietary wolfberry could be beneficial to retinoprotection through reversal of mitochondrial function in diabetic mice.

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