Porcine 2 ', 5 '-oligoadenylate synthetase 2 inhibits porcine reproductive and respiratory syndrome virus replication in vitro

文献类型: 外文期刊

第一作者: Zhao, Mengmeng

作者: Zhao, Mengmeng;Wan, Bo;He, Jian;Zhang, Gaiping;Li, Huawei;Chen, Xinxin;Wang, Linjian;Wang, Yinbiao;Xie, Sha;Qiao, Songlin;Zhang, Gaiping;Zhang, Gaiping

作者机构:

关键词: Porcine reproductive and respiratory syndrome virus;2 ', 5 '-oligoadenylate synthetase;RIG-1;Replication;Porcine alveolar macrophages;RNase L

期刊名称:MICROBIAL PATHOGENESIS ( 影响因子:3.738; 五年影响因子:3.663 )

ISSN: 0882-4010

年卷期: 2017 年 111 卷

页码:

收录情况: SCI

摘要: Porcine reproductive and respiratory syndrome virus (PRRSV) is acknowledged a fulminating infectious pathogen affecting the pig farming industry, and current vaccines and drugs could hardly inhibit this virus. The 2', 5'-oligoadenylate synthetase (OASs) have antiviral activities, but the role(s) played by porcine OAS2 in protection against PRRSV infection are unknown. Here we found that endogenous expression of the porcine OAS2 gene could be promoted by interferon (IFN)-beta or PRRSV infection in porcine alveolar macrophages. Knockdown of porcine OAS2 led to increases in PRRSV replication, and OAS2 expression suppressed replication of PRRSV in a retinoic acid inducible gene I (RIG-I)-dependent manner, anti-PRRSV activity of porcine OAS2 would be lost if RNase L and OAS2 were both silenced. This discovery illustrates a pathway that porcine OAS2 responses to host anti-PRRSV function. (C) 2017 Published by Elsevier Ltd.

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