Porcine Fc gamma RIIb Mediates Enhancement of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Infection

文献类型： 外文期刊

第一作者： Qiao, Songlin

作者： Qiao, Songlin;Jiang, Zhizheng;Tian, Xiaohui;Wang, Rui;Xing, Guangxu;Wan, Bo;Bao, Dengke;Liu, Yonghui;Hao, Huifang;Guo, Junqing;Zhang, Gaiping

作者机构：

期刊名称：PLOS ONE （ 影响因子：3.24； 五年影响因子：3.788 ）

ISSN： 1932-6203

年卷期： 2011 年 6 卷 12 期

页码：

收录情况： SCI

摘要： Antibody-dependent enhancement (ADE) of virus infection caused by the uptake of virus-antibody complexes by Fc gamma Rs is a significant obstacle to the development of effective vaccines to control certain human and animal viral diseases. The activation Fc gamma Rs, including Fc gamma RI and Fc gamma RIIa have been shown to mediate ADE infection of virus. In the present paper, we showed that pocine Fc gamma RIIb, an inhibitory Fc gamma R, mediates ADE of PRRSV infection. Stable Marc-145 cell lines expressing poFc gamma RIIb (Marc-poFc gamma RII) were established. The relative yield of progeny virus was significantly increased in the presence of sub-neutralization anti-PRRSV antibody. The Fab fragment and normal porcine sera had no effect. Anti-poFc gamma RII antibody inhibited the enhancement of infection when cells were infected in the presence of anti-PRRSV antibody, but not when cells were infected in the absence of antibody. These results indicate that enhancement of infection in these cells by anti-PRRSV virus antibody is Fc gamma RII-mediated. Identification of the inhibitory Fc gamma R mediating ADE infection should expand our understanding of the mechanisms of pathogenesis for a broad range of infectious diseases and may open many approaches for improvements to the treatment and prevention of such diseases.

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