New insights into the prolactin-RsaI (PRL-RsaI) locus in Chinese Holstein cows and its effect on milk performance traits
文献类型： 外文期刊
第一作者： Dong, C. H.
作者： Dong, C. H.;Zhou, J. P.;Song, X. M.;Zhang, L.;Jiang, J. F.;Jiang, Y. Q.
作者机构：
关键词： PRL-RsaI locus;Milk performance traits;Chinese Holstein cow
期刊名称：GENETICS AND MOLECULAR RESEARCH （ 影响因子：0.764； 五年影响因子：0.912 ）
ISSN： 1676-5680
年卷期： 2013 年 12 卷 4 期
页码：
收录情况： SCI
摘要： Prolactin (PRL) plays central roles in mammals' reproduction, gland development, milk secretion, and the expression of milk protein genes. In dairy cattle, the PRL gene is a potential quantitative trait locus and genetic marker related to milk performance traits. Here, a total of 586 randomly selected Chinese Holstein cows were genotyped for locus PRL-RsaI. One haplotype block containing eight SNPs was identified in the region from intron 3 to intron 4 of the PRL gene in Chinese Holstein cows. One tag SNP (7545 G -> A) was selected to represent the haplotype block defined by the genotypic data. The cows with genotype AA of this tag SNP had a higher milk yield at 305 days (8457 +/- 938 kg) than the cows with GA (7537 +/- 1278 kg; P < 0.01) or GG (7757 +/- 1174 kg; P < 0.05). This suggests that the haplotype block examined in this study contains important markers for milk production traits in Chinese Holstein cows.
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