Effects of Lactobacillus plant arum on genes expression pattern in mice jejunal Peyer's patches
文献类型： 外文期刊
第一作者： Chang, Guifang
作者： Chang, Guifang;Shi, Yonghui;Le, Guowei;Sun, Jin;Li, Jianing;Xu, Ziwei
作者机构：
关键词： DNA-micro array;Jejunal Peyer's patches;Lactobacillus plant arum Lp6
期刊名称：CELLULAR IMMUNOLOGY （ 影响因子：4.868； 五年影响因子：4.706 ）
ISSN： 0008-8749
年卷期： 2009 年 258 卷 1 期
页码：
收录情况： SCI
摘要： Jejunal Peyer's patches contain specialized epithelial M cells that take up ingested microorganisms from the lumen of the gut by transcytosis. Using DNA-micro array, we analyzed the gene expression patterns of jejunal Peyer's patches in order to gain insight into the molecular mechanism by which Lp6 interacted with the host organism in a gnotobiotic environment v. in the gut normal microflora. The micro array data revealed that, among approximately 14,000 genes, 420 were expressed in Lp6 administration group at twofold or higher levels compared to the control group. These included genes involved in immune response, and cell differentiation, cell-cell signaling, cell adhesion, signal transcription, and transduction. Real-time PCR confirmed the reliability of the analysis. These data indicated that administration of Lactobacillus Lp6 was associated with a complex genetic response in the jejunal Peyer's patches. (C) 2009 Published by Elsevier Inc.
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