文献类型： 外文期刊

第一作者： Bao, GL

作者： Bao, GL;Tong, CG;Wei, Q;Ji, QA

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期刊名称：PROCEEDINGS OF THE 6TH WORLD RABBIT CONGRESS, VOLS 1-3: VOL 1: NUTRITION, WOOL & FUR; VOL 2: REPRODUCTION & REPRODUCTION PHYSIOLOGY - GENETICS & SELECTION - GENERAL PHYSIOLOGY - ETHOLOGY & WELFARE; VOL 3: PATHOLOGY & PROPHYLAXIS - GROWTH & MEAT - MANAGEMENT & PRODUCTION

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年卷期： 1998 年

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收录情况： SCI

摘要： Rabbit haemorrhagic disease (RHD), Bordetella bronchiseptica (Bb) disease and Pasteurella multocida (Pm) disease are three main infectious diseases in rabbits. The number of Db and Pm cultivated by the new method of liquid cultivation developed in our laboratory reached 1.86-2.3 x 10(10) and 2-2.6 +/- 10(10) living cells/ml, respectively. Every rabbit in immunised groups was inoculated subcutaneously with a dose of 1 mi tripler vaccine prepared with RHD, Bb and Pm. The immune protective rate against RHD was 100% (28/28) 5 days after vaccination and 6.5 months later the efficiency of immunity remains 100% (23/23). The average rates of protection against Bb and Pm 10-14 after vaccination were 88.9% (24/27) and 88.5% (23/26), and were 72.7% (8/11) and 75.0 (9/12) 6.5 months later. The tripler vaccine was stored more than 6 months in refrigerator (4-8 degrees C) or 4 to 6 month at room temperature (<25 degrees C) without reduction of efficiency. Dynamics of the antibody were consistent with results of the challenge. The results from vaccination of mom than 295 000 rabbits in the field showed the good safety and the efficacy of the vaccine.

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