文献类型： 外文期刊
第一作者： Zhang, Tao
作者： Zhang, Tao;Wang, Suyan;Liu, Yongzhen;Qi, Xiaole;Gao, Yulong;Gao, Yulong;Gao, Yulong;Gao, Yulong
作者机构：
关键词： IBD; IBDV; immunosuppression; adaptive immune response; lymphocytes
期刊名称：FRONTIERS IN IMMUNOLOGY （ 影响因子：7.3； 五年影响因子：8.0 ）
ISSN： 1664-3224
年卷期： 2024 年 14 卷
页码：
收录情况： SCI
摘要： Infectious bursal disease (IBD) is an acute, highly infectious, and immunosuppressive disease caused by the infectious bursal disease virus (IBDV), which interferes with the immune system, causes hypoimmunity and seriously threatens the healthy development of the poultry industry. Adaptive immune response, an important defense line of host resistance to pathogen infection, is the host-specific immune response mainly mediated by T and B lymphocytes. As an important immunosuppressive pathogen in poultry, IBDV infection is closely related to the injury of the adaptive immune system. In this review, we focus on recent advances in adaptive immune response influenced by IBDV infection, especially the damage on immune organs, as well as the effect on humoral immune response and cellular immune response, hoping to provide a theoretical basis for further exploration of the molecular mechanism of immunosuppression induced by IBDV infection and the establishment of novel prevention and control measures for IBD.
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