Sedative effects of Arachis hypogaea L. stem and leaf extracts on sleep-deprived rats

文献类型： 外文期刊

第一作者： Zu, Xiaoyan

作者： Zu, Xiaoyan;Xiong, Guangquan;Liao, Tao;Qiao, Yu;Geng, Shengrong;Li, Xin;Zhang, Zhenya;Li, Yiting

作者机构：

关键词： Arachis hypogaea L. stem and leaf;sedative effects;rat;sleep deprivation;linalool

期刊名称：EXPERIMENTAL AND THERAPEUTIC MEDICINE （ 影响因子：2.447； 五年影响因子：2.263 ）

ISSN： 1792-0981

年卷期： 2013 年 6 卷 2 期

页码：

收录情况： SCI

摘要： Arachis hypogaea L. stem and leaf extracts (AHSLE) are reputed to aid sleep. The purpose of this study was to evaluate the sedative effects of AHSLE on sleep-deprived (SD) rats and the effect on energy system pathways. Furthermore, we analyzed the essential oil components of Arachis hypogaea L. stems and leaves (AHSL) to explain the sedative effects. AHSLE were obtained by extracting AHSL twice with water at 98 degrees C for 3 h. Animal experiments were performed in the Laboratory Animal Resource Center, University of Tsukuba, Japan, and the levels of neurotransmitters were analyzed by high performance liquid chromatography (HPLC). The essential oil of the AHSL was obtained by simultaneous distillation and extraction (SDE) and analyzed by gas chromatography-mass spectrometry (GC-MS). Following treatment with AHSLE, the adenosine triphosphate (ATP) levels of the SD rats increased, which is a different effect from that previously observed in freely behaving rats. Adenosine (Ad) were not elevated by AHSLE uniformly throughout the brain, but accumulated in site-specific and time-prolonged manners. Following GC-MS analysis of the AHSL essential oil, a total of 37 compounds were identified; the major components were linalool (16.17%, which has sedative-like activity), n-hexadecanoic acid (16.42%), and 1-octen-3-ol (8.48%; a product of linalool decomposition). AHSLE affect the target neurotransmitters related to the rat circadian rhythms in specific brain regions, suggesting that AHSLE have the potential to increase sleep during the SD phase, and the sedative effects of AHSLE may be due to high levels of linalool and its decomposition products. AHSLE are potentially useful as sedatives or sleep aids in hypnotic therapy.

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