Lanostane-type triterpenoids from the fruiting body of Ganoderma calidophilum

文献类型: 外文期刊

第一作者: Huang, Sheng-Zhuo

作者: Huang, Sheng-Zhuo;Ma, Qing-Yun;Kong, Fan-Dong;Guo, Zhi-Kai;Cai, Cai-Hong;Hu, Li-Li;Zhou, Li-Man;Wang, Qi;Dai, Hao-Fu;Mei, Wen-Li;Zhao, You-Xing

作者机构:

关键词: Ganoderma calidophilum;Ganodermataceae;Lanostane triterpenoid;Cytotoxic activity

期刊名称:PHYTOCHEMISTRY ( 影响因子:4.072; 五年影响因子:4.132 )

ISSN: 0031-9422

年卷期: 2017 年 143 卷

页码:

收录情况: SCI

摘要: To search for active anti-cancer constituents in the fruiting body of Ganoderma calidophilum, we have successfully isolated four previously undescribed spiro-lactone lanostane triterpenoids (spiroganocalitones A-D), two previously undescribed lanostanoids (ganodecalones A and B) together with twenty-three known ones. The structures of the six previously undescribed compounds were elucidated based on 1D, 2D-NMR, and HRMS analyses. Ganoderone A showed moderate cytotoxic activity against K562, BEL7402, and SGC790 cell lines with IC50 values of 7.62, 6.28, and 3.55 mu M, respectively. (C) 2017 Elsevier Ltd. All rights reserved.

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