Chrodrimanins O-S from the fungus Penicillium. sp SCS-KFD09 isolated from a marine worm, Sipunculusnudus

文献类型： 外文期刊

第一作者： Kong, Fan-Dong

作者： Kong, Fan-Dong;Ma, Qing-Yun;Xie, Qing-Yi;Wang, Pei;Chen, Peng-Wei;Zhou, Li-Man;Dai, Hao-Fu;Zhao, You-Xing;Luo, Du-Qiang;Zhang, Ren-Shuai

作者机构：

关键词： Penicillitun sp.;Chrodrimanins;Fungus;Protein tyrosine phosphatase 1B inhibition

期刊名称：FITOTERAPIA （ 影响因子：2.882； 五年影响因子：3.202 ）

ISSN： 0367-326X

年卷期： 2017 年 122 卷

页码：

收录情况： SCI

摘要： Five new meroterpenoids, chrodrimanins O-S (1-5), as well as a known one (6), were isolated from the fermentation broth of Penicillium sp. SCS-ICED09 isolated from a marine worm, Sipunculusnudus, from Haikou Bay, China. The structures including the absolute configurations of the new compounds were unambiguously elucidated by spectroscopic data and ECD spectra analysis along with quantum ECD calculations. Among them, compound 1 represents the first example of an unusual trichlorinated meroterpenoid with an unique dichlorine functionality. Compounds 1 and 4-6 displayed inhibitory activity of protein tyrosine phosphatase 1B (PTP1B) with IC50 values of 71.6, 62.5, 63.1, and 39.6 mu M, respectively, and showed no apparent activity against three tumor cell lines (A549, HepG2, and Hela) and human umbilical vein endothelial cells (HUVEC) at 10 mu M.

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