Comprehensive analysis of 1,771 transcriptomes from 7 tissues enhance genetic and biological interpretations of maize complex traits
文献类型： 外文期刊
第一作者： Lei, Mengyu
作者： Lei, Mengyu;Si, Huan;Ji, Yan;Liu, Zhengwen;Zhao, Jiarui;Zan, Yanjun;Lei, Mengyu;Zhu, Mingjia;Han, Yu;Liu, Wei;Han, Yu;Liu, Wei;Dai, Yifei;Hao, Fan;Hao, Ran;Ye, Guoyou;Zan, Yanjun;Zan, Yanjun
作者机构：
关键词： GWAS; regulatory variants; integrative genomics; complex trait
期刊名称：G3-GENES GENOMES GENETICS （ 影响因子：2.2； 五年影响因子：2.5 ）
ISSN： 2160-1836
年卷期： 2025 年 15 卷 9 期
页码：
收录情况： SCI
摘要： By reanalyzing 1,771 RNA-seq datasets from 7 tissues in a maize diversity panel, we explored the landscape of multi-tissue transcriptome variation, evolution patterns of tissue-specific genes, and built a comprehensive multi-tissue gene regulation atlas to understand the genetic regulation of maize complex traits. Through an integrative analysis of tissue-specific gene regulatory variation with genome-wide association studies, we detected relevant tissue types and several candidate genes for a number of agronomic traits, including leaf during the day for the anthesis-silking interval, leaf during the day for kernel Zeinoxanthin level, and root for ear height, highlighting the potential contribution of tissue-specific gene expression to variation in agronomic traits. Using transcriptome-wide association and colocalization analysis, we associated tissue-specific expression variation of 74 genes to agronomic traits variation. Our findings provide novel insights into the genetic and biological mechanisms underlying maize complex traits, and the multi-tissue regulatory atlas serves as a primary source for biological interpretation, functional validation, and genomic improvement of maize.
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