Aspergiloid I, an unprecedented spirolactone norditerpenoid from the plant-derived endophytic fungus Aspergillus sp YXf3

文献类型: 外文期刊

第一作者: Guo, Zhi Kai

作者: Guo, Zhi Kai;Wang, Rong;Huang, Wei;Jiang, Rong;Tan, Ren Xiang;Ge, Hui Ming;Li, Xiao Nian

作者机构:

关键词: Aspergillus;endophytic fungus;Ginkgo biloba;natural product;norditerpenoid;Trichocomaceae

期刊名称:BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY ( 影响因子:2.883; 五年影响因子:2.785 )

ISSN: 1860-5397

年卷期: 2014 年 10 卷

页码:

收录情况: SCI

摘要: An unusual C-18 norditerpenoid, aspergiloid I (1), was isolated from the culture broth of Aspergillus sp. YXf3, an endophytic fungus derived from Ginkgo biloba. Its structure was unambiguously established by analysis of HRMS-ESI and spectroscopic data, and the absolute configuration was determined by low-temperature (100 K) single crystal X-ray diffraction with Cu K alpha radiation. This compound is structurally characterized by a new carbon skeleton with an unprecedented 6/5/6 tricyclic ring system bearing an alpha,beta-unsaturated spirolactone moiety in ring B, and represents a new subclass of norditerpenoid, the skeleton of which is named aspergilane. The hypothetical biosynthetic pathway for 1 was also proposed. The cytotoxic, antimicrobial, anti-oxidant and enzyme inhibitory activities of 1 were evaluated.

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