2-(2-Phenylethyl)chromone Derivatives in Chinese Agarwood "Qi-Nan" from Aquilaria sinensis

文献类型： 外文期刊

第一作者： Yang, De Lan

作者： Yang, De Lan;Mei, Wen Li;Zeng, Yan Bo;Guo, Zhi Kai;Zhao, You Xing;Wang, Hao;Zuo, Wen Jian;Dong, Wen Hua;Wang, Qing Huang;Dai, Hao Fu;Yang, De Lan;Mei, Wen Li;Zeng, Yan Bo;Guo, Zhi Kai;Zhao, You Xing;Wang, Hao;Zuo, Wen Jian;Dong, Wen Hua;Wang, Qing Huang;Dai, Hao Fu;Yang, De Lan

作者机构：

关键词： Aquilaria sinensis;Thymelaeaceae;Qi-Nan;2-(2-phenylethyl)chromone derivatives;AChE inhibitory activities

期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）

ISSN： 0032-0943

年卷期： 2013 年 79 卷 14 期

页码：

收录情况： SCI

摘要： Five new 2-(2-phenylethyl)chromone derivatives, qinanones A-E (1-5), together with eight known 2-(2-phenylethyl)chromone derivatives (6-13), were isolated from the Et2O extract of high-quality Chinese agarwood Qi-Nan originating from Aquilaria sinensis. The structures of the new 2-(2-phenylethyl)chromones were elucidated by spectroscopic techniques (UV, IR, 1D and 2D NMR) and MS analyses. In the bioassay for acetylcholinesterase inhibitors, compounds 1-6, 10, and 12 exhibited weak inhibitory activities (inhibition percentage ranged from 10 % to 24 % at the concentration of 50 mu g/mL). Compared with other agarwoods, Qi-Nan was different in containing 2-(2-phenylethyl)chromones with unsubstituted chromone rings.

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