New Azalomycin F Analogs from Mangrove Streptomyces sp 211726 with Activity against Microbes and Cancer Cells
文献类型: 外文期刊
第一作者: Yuan, Ganjun
作者: Yuan, Ganjun;Yuan, Ganjun;Hong, Kui;Lin, Haipeng;Yuan, Ganjun;Hong, Kui;She, Zhigang;Li, Jia
作者机构:
关键词: azalomycin F;Streptomyces sp 211726;cytotoxicity;antimicrobial activity
期刊名称:MARINE DRUGS ( 影响因子:5.118; 五年影响因子:5.951 )
ISSN: 1660-3397
年卷期: 2013 年 11 卷 3 期
页码:
收录情况: SCI
摘要: Seven new azalomycin F analogs (1-7) were isolated from the broth of mangrove Streptomyces sp. 211726, and respectively identified as 25-malonyl demalonylazalomycin F-5a monoester (1), 23-valine demalonylazalomycin F-5a ester (2), 23-(6-methyl) heptanoic acid demalonylazalomycins F-3a ester (3), F-4a ester (4) and F-5a ester (5), 23-(9-methyl) decanoic acid demalonylazalomycin F-4a ester (6) and 23-(10-methyl) undecanoic acid demalony lazalomycin F-4a ester (7). Their structures were established by their spectroscopic data and by comparing with those of azalomycins F-3a, F-4a and F-5a. Biological assays exhibited that 1-7 showed broad-spectrum antimicrobial and anti HCT-116 activities.
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