Homoisoflavonoids from the medicinal plant Portulaca oleracea

文献类型： 外文期刊

第一作者： Yan, Jian

作者： Yan, Jian;Zhou, Zhong-Yu;Tan, Jian-Wen;Sun, Li-Rong;Chen, Yu-Chan;Zhang, Wei-Min;Dai, Hao-Fu

作者机构：

关键词： Portulaca oleracea;Portulacaceae;Homoisoflavonoid;Portulacanone;Cytotoxic activity

期刊名称：PHYTOCHEMISTRY （ 影响因子：4.072； 五年影响因子：4.132 ）

ISSN： 0031-9422

年卷期： 2012 年 80 卷

页码：

收录情况： SCI

摘要： Four homoisoflavonoids named portulacanones A-D, identified as 2'-hydroxy-5,7-dimethoxy-3-benzyl-chroman-4-one, 2'-hydroxy-5,6,7-trimethoxy-3-benzyl-chroman-4-one, 5,2'-dihydroxy-6,7-dimethoxy-3-benzyl-chroman-4-one, and 5,2'-dihydroxy-7-methoxy-3-benzylidene-chroman-4-one, were isolated from aerial parts of the plant Portulaca oleracea along with nine other known metabolites. Their structures were established on the basis of extensive spectroscopic analyses. Portulacanones A-D is the first group of homoisoflavonoids so far reported from the family Portulacaceae. They represent a rare subclass of homoisoflavonoids in nature with a structural feature of a single hydroxyl group substituted at C-2' rather than at C-4' in ring B of the skeleton. Three homoisoflavonoids and the known compound 2,2'-dihydroxy-4',6'-dimethoxychalcone selectively showed in vitro cytotoxic activities towards four human cancer cell lines. Especially 2,2'-dihydroxy-4',6'-dimethoxychalcone showed cytotoxic activity against cell line SGC-7901 with an IC50 value of 1.6 mu g/ml, which was more potent than the reference compound mitomycin C (IC50 13.0 mu g/ml). (C) 2012 Elsevier Ltd. All rights reserved.

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