Actinotetraoses A-H: Tetrasaccharide Derivatives from a Grasshopper-Associated Amycolatopsis sp HCa1
文献类型： 外文期刊
第一作者： Guo, Zhi Kai
作者： Guo, Zhi Kai;Zhang, Gao Fei;Jiao, Rui Hua;Shen, Yan;Xu, Qiang;Tan, Ren Xiang;Ge, Hui Ming;Guo, Zhi Kai;Guo, Zhi Kai
作者机构：
关键词： Amycolatopsis;Pseudonocardiaceae;insect-derived actinomycete;tetrasaccharide derivatives
期刊名称：PLANTA MEDICA （ 影响因子：3.352； 五年影响因子：3.4 ）
ISSN： 0032-0943
年卷期： 2012 年 78 卷 10 期
页码：
收录情况： SCI
摘要： Chemical investigation of the insect-derived actinomycete Amycolatopsis sp. HCa1 with NMR-guided fractionation led to the isolation of eight new tetrasaccharide derivatives containing an unusual nonreducing glucotetraose skeleton, named actinotetraoses A-H (1-8), and one known compound, tigloside (9). The structures of these compounds were determined on the basis of analyses of their spectroscopic data. The in vitro immunosuppressive activity and cytotoxicity of these compounds were evaluated by T cell viability and MTT assays, respectively. Only actinotetraose E (5) displayed weak immunosuppressive activity.
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