Cytochalasin. D, a tropical fungal metabolite, inhibits CT26 tumor growth and angiogenesis

文献类型： 外文期刊

第一作者： Huang, Feng Ying

作者： Huang, Feng Ying;Li, Yue Nan;Tan, Guang Hong;Huang, Feng Ying;Li, Yue Nan;Mei, Wen Li;Dai, Hao Fu;Zhou, Peng;Huang, Feng Ying;Li, Yue Nan;Mei, Wen Li;Dai, Hao Fu;Zhou, Peng

作者机构：

关键词： Cytochalasin D;CT26 colorectal carcinoma;Apoptosis;Tumor angiogenesis

期刊名称：ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE （ 影响因子：1.226； 五年影响因子：2.285 ）

ISSN： 1995-7645

年卷期： 2012 年 5 卷 3 期

页码：

收录情况： SCI

摘要： Objective: To investigate whether cytochalasin D can induce antitumor activities in a tumor model. Methods: Murnie CT26 colorectal carcinoma cells were cultured in vitro and cytochalasin D was used as a cytotoxic agent in rimed its capabilities of inhibiting CT26 cell proliferation and inducing cell apoptosis by MTT and it TUNEL-based apoptosis assay. Murine CT26 tumor model was established in observe. the tumor growth and survival time. Tumor tissues were used to detect the microvessel density by immunohistochemistry. In addition. alginate encapsulated tumor cell assay was used to quantify the tumor angiogenesis in vivo. Results: Cytochalasin D inhibited CT26 tumor cell proliferation in lime and close dependent manner and induced significant CT26 cell apoptosis, which almost reached the level induced by the positive control nuclease. The optimum effective (lose of cytochalasin D for in vivo therapy was about 50 mg/kg. Cytochalasin in Vino treatment significantly inhibited tumor growth and prolonged the survival times in CT26 tumor-hearing mice. The results of immunohistochemistry analysis and alginate encapsulation assay indicated that the cytochalasin D could effectively inhibited tumor angiogenesis. Conclusions: Cytochalasin D inhibits CT26 tumor growth potentially through inhibition of cell proliferation, induction of cell apoptosis and suppression of tumor angiogenesis.

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