A new staurosporine analog from Actinomycetes Streptomyces sp (172614)

文献类型: 外文期刊

第一作者: Li, Xiao-Bin

作者: Li, Xiao-Bin;Tang, Jin-Shan;Gao, Hao;Yao, Xin-Sheng;Ding, Rong;Yao, Xin-Sheng;Li, Jia;Hong, Kui

作者机构:

关键词: Streptomyces sp.;staurosporine analog;cytotoxicity;HCT 116

期刊名称:JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH ( 影响因子:1.569; 五年影响因子:1.598 )

ISSN: 1028-6020

年卷期: 2011 年 13 卷 8 期

页码:

收录情况: SCI

摘要: A new staurosporine analog, 10'-{5 ''-[(methoxycarbonyl) amino]-2 ''-methyl}-phenylaminocarbonylstaurosporine (1), together with staurosporine (2), was obtained from the culture broth of Actinomycetes Streptomyces sp. (172614). Their structures were elucidated by comprehensive spectroscopic analysis including UV, MS, NMR, and CD spectra. Pharmacological experiments revealed that 1 and 2 showed significant cytotoxicity against human colon tumor cell HCT-116.

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