A new cytotoxic homoisoflavonoid from Dracaena cambodiana
文献类型: 外文期刊
第一作者: Liu, Jian
作者: Liu, Jian;Mei, Wen-Li;Wu, Jiao;Peng, Ming;Dai, Hao-Fu;Zhao, You-Xing
作者机构:
关键词: Dracaena cambodiana;Agavaceae;homoisoflavonoid;cytotoxicity;cambodianol
期刊名称:JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH ( 影响因子:1.569; 五年影响因子:1.598 )
ISSN: 1028-6020
年卷期: 2009 年 11 卷 2 期
页码:
收录情况: SCI
摘要: A new homoisoflavonoid, named cambodianol (1), together with the two known flavanes, (2S)-7,3'-dihydroxy-4'-methoxy-8-methylflavane (2) and (2R)-7,4'-dihydroxy-8-methylflavane (3), were isolated from the stems of Dracaena cambodiana. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (UV, IR, 1D-, and 2D-NMR). Compound 1 exhibited significant cytotoxic activities against K562 and SGC-7901 with the IC50 values of 1.4 and 2.9g/ml, respectively.
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