A new cytotoxic homoisoflavonoid from Dracaena cambodiana

文献类型： 外文期刊

第一作者： Liu, Jian

作者： Liu, Jian;Mei, Wen-Li;Wu, Jiao;Peng, Ming;Dai, Hao-Fu;Zhao, You-Xing

作者机构：

关键词： Dracaena cambodiana;Agavaceae;homoisoflavonoid;cytotoxicity;cambodianol

期刊名称：JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH （ 影响因子：1.569； 五年影响因子：1.598 ）

ISSN： 1028-6020

年卷期： 2009 年 11 卷 2 期

页码：

收录情况： SCI

摘要： A new homoisoflavonoid, named cambodianol (1), together with the two known flavanes, (2S)-7,3'-dihydroxy-4'-methoxy-8-methylflavane (2) and (2R)-7,4'-dihydroxy-8-methylflavane (3), were isolated from the stems of Dracaena cambodiana. Their structures were determined based on HR-ESI-MS and spectroscopic techniques (UV, IR, 1D-, and 2D-NMR). Compound 1 exhibited significant cytotoxic activities against K562 and SGC-7901 with the IC50 values of 1.4 and 2.9g/ml, respectively.

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