Cytotoxic Constituents from Marine Actinomycete Streptomyces sp 124092

文献类型: 外文期刊

第一作者: Xie Xiu-Chao

作者: Xie Xiu-Chao;Mei Wen-Li;Zeng Yan-Bo;Lin Hai-Peng;Zhuang Ling;Dai Hao-Fu;Hong Kui;Xie Xiu-Chao

作者机构:

关键词: Marine actinomycete;Streptomyces sp.;Cytotoxicity;Isolation and purification

期刊名称:CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE ( 影响因子:0.65; 五年影响因子:0.481 )

ISSN: 0251-0790

年卷期: 2008 年 29 卷 11 期

页码:

收录情况: SCI

摘要: To study the cytotoxic constituents from marine actinomycete Streptomyces sp. (124092) of rhizosphere soil of mangrove plant Heritiera littoralis, five compounds were isolated by column chromatography from the fermentation broth of marine actinomycete Streptomyces sp. (124092 Their structures were elucidated as p-tolyl 3-aminopropanoate(1) 6-amino-3-(4-hydroxybenzyl) -1, 4-diazonane-2,5-dione(2), n-butyl mannoside(3), daidzein(4), and indole-g-carboxylic acid(5), by MS, NMR, (1)H-(1)H COSY, HMQC, and HMBC spectra. Among them, compounds I and 2 are new compounds. Cytotoxic bioassay results show that compounds 1-4 possess inhibitory effects on human hepatoma SMMC-7721 cell line in vitro.

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