Complexation of carbendazim with hydroxypropyl-beta-cyclodextrin to improve solubility and fungicidal activity

文献类型: 外文期刊

第一作者: Ge, Xia

作者: Ge, Xia;Huang, Zheng;Tian, Shilong;Huang, Yulong;Zeng, Chaozhen

作者机构:

关键词: Carbendazim;Hydroxypropyl-beta-cyclodextrin;Inclusion complex;Solubility;Fungicidal activity

期刊名称:CARBOHYDRATE POLYMERS ( 影响因子:9.381; 五年影响因子:8.678 )

ISSN: 0144-8617

年卷期: 2012 年 89 卷 1 期

页码:

收录情况: SCI

摘要: The effect of hydroxypropyl-beta-cyclodextrin (HP beta CD) on the improvement of the solubility and fungicidal activity of carbendazim (MBC) has been investigated. The inclusion complexation of HP beta CD with MBC has been prepared and characterized by phase solubility diagram, fluorescence, H-1 NMR, ROESY and FT-IR spectra. The stoichiometric ratio and stability constant were determined by Job's plot and phase solubility studies, respectively. The inclusion complex MBC.HP beta CD has exhibited different properties from MBC. The obtained inclusion complex was found to significantly improve the water solubility of MBC. In addition, the biological activity indicated that the complex displayed the better fungicidal activity than MBC. The present study provided useful information for a more rational application of MBC. (c) 2012 Elsevier Ltd. All rights reserved.

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