Genesis, Evolution and Prevalence of H5N6 Avian Influenza Viruses in China

文献类型： 外文期刊

第一作者： Bi, Yuhai

作者： Bi, Yuhai;Zou, Rongrong;Liu, Yingxia;Gao, George Fu;Bi, Yuhai;Chen, Quanjiao;Wang, Qianli;Chen, Jianjun;Wu, Jun;Zhao, Lihua;Li, Mingxin;Liu, Di;Gao, George Fu;Bi, Yuhai;Wang, Qianli;Wong, Gary;Wu, Jun;Liu, Di;Gao, George Fu;Chen, Quanjiao;Chen, Jianjun;Zhao, Lihua;Li, Mingxin;Jin, Tao;Xu, Xun;Quan, Chuansong;Liu, Jun;Gao, George Fu;Yin, Renfu;Ding, Zhuang;Xu, Wen;Li, Hong;Lu, Lin;Wang, Huijun;Tian, Kegong;Fu, Guanghua;Huang, Yu;Shestopalov, Alexander;Li, Shoujun;Xu, Bing;Yu, Hongjie;Luo, Tingrong;Shi, Weifeng;Liu, Di;Luo, Yang;Gao, George Fu

作者机构：

期刊名称：Cell Host & Microbe （ 影响因子：21.023； 五年影响因子：22.103 ）

ISSN： 1931-3128

年卷期： 2016 年 20 卷 6 期

页码：

收录情况： SCI

摘要： Constant surveillance of live poultry markets (LPMs) is currently the best way to predict and identify emerging avian influenza viruses (AIVs) that pose a potential threat to public health. Through surveillance of LPMs from 16 provinces and municipalities in China during 2014-2016, we identified 3,174 AIV-positive samples and isolated and sequenced 1,135 AIVs covering 31 subtypes. Our analysis shows that H5N6 has replaced H5N1 as one of the dominant AIV subtypes in southern China, especially in ducks. Phylogenetic analysis reveals that H5N6 arose from reassortments of H5 and H6N6 viruses, with the hemagglutinin and neuraminidase combinations being strongly lineage specific. H5N6 viruses constitute at least 34 distinct genotypes derived from various evolutionary pathways. Notably, genotype G1.2 virus, with internal genes from the chicken H9N2/H7N9 gene pool, was responsible for at least five human H5N6 infections. Our findings highlight H5N6 AIVs as potential threats to public health and agriculture.

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