Effect of Vitamin A Supplementation on Growth Performance, Serum Biochemical Parameters, Intestinal Immunity Response and Gut Microbiota in American Mink (Neovison vison)

文献类型： 外文期刊

第一作者： Nan, Weixiao

作者： Nan, Weixiao;Si, Huazhe;Yang, Qianlong;Shi, Hongpeng;Zhang, Tietao;Li, Guangyu;Liu, Hanlu;Nan, Weixiao;Si, Huazhe;Shi, Qiumei;Zhang, Haihua

作者机构：

关键词： vitamin A; mink; growth performance; IL-22; villus height; Akkermansia

期刊名称：ANIMALS （ 影响因子：2.752； 五年影响因子：2.942 ）

ISSN： 2076-2615

年卷期： 2021 年 11 卷 6 期

页码：

收录情况： SCI

摘要： Simple Summary Vitamin A is critical throughout life, but utilization of vitamin A often results in local and systemic toxicity. This study investigated the effect of vitamin A supplementation on mink growth and health. The results show that vitamin A deficiency decreased the ADG, villus height, villus height/crypt depth ratio and mRNA expression levels of IL-22, Occludin and ZO-1. Vitamin A supplementation increased the diversity of jejunum bacteria, decreased the ratio of Firmicutes to Bacteroidetes and increased the relative abundance of Akkermansia and Lachnospiraceae NK4A136 group. This experiment investigated the effect of vitamin A supplementation on growth, serum biochemical parameters, jejunum morphology and the microbial community in male growing-furring mink. Thirty healthy male mink were randomly assigned to three treatment groups, with 10 mink per group. Each mink was housed in an individual cage. The mink in the three groups were fed diets supplemented with vitamin A acetate at dosages of 0 (CON), 20,000 (LVitA) and 1,280,000 IU/kg (HVitA) of basal diet. A 7-day pretest period preceded a formal test period of 45 days. The results show that 20,000 IU/kg vitamin A increased the ADG, serum T-AOC and GSH-Px activities, villus height and villus height/crypt depth ratio (p < 0.05). The mRNA expression levels of IL-22, Occludin and ZO-1 in the jejunum of mink were significantly higher in the LVitA group than those in the CON and HVitA groups (p < 0.05). Vitamin A supplementation increased the diversity of jejunum bacteria, decreased the ratio of Firmicutes to Bacteroidetes and increased the relative abundance of Akkermansia, uncultured bacterium f Muribaculaceae, Allobaculum, Lachnospiraceae NK4A136 group, Rummeliibacillus and Parasutterella. The comparison of potential functions also showed enrichment of glycan biosynthesis and metabolism, transport and catabolism pathways in the vitamin A supplementation groups compared with the CON group. In conclusion, these results indicate that dietary vitamin A supplementation could mediate host growth by improving intestinal development, immunity and the relative abundance of the intestinal microbiota.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序