Whole-genome resequencing and RNA-seq analysis implicates GPR75 as a potential genetic basis related to retarded growth in South China carp ( Cyprinus carpio rubrofuscus) )

文献类型： 外文期刊

第一作者： Zhong, Zaixuan

作者： Zhong, Zaixuan;Fan, Jiajia;Tian, Yuanyuan;Lin, Minhui;Zhu, Huaping;Ma, Dongmei;Zhong, Zaixuan;Fan, Jiajia;Tian, Yuanyuan;Lin, Minhui;Zhu, Huaping;Ma, Dongmei;Zhong, Zaixuan;Fan, Jiajia;Tian, Yuanyuan;Lin, Minhui;Zhu, Huaping;Ma, Dongmei

作者机构：

关键词： Whole-genome resequencing; South China carp; Retarded growth; Gpr75

期刊名称：GENOMICS （ 影响因子：3.0； 五年影响因子：3.3 ）

ISSN： 0888-7543

年卷期： 2024 年 116 卷 5 期

页码：

收录情况： SCI

摘要： The south China carp ( Cyprinus carpio rubrofuscus) ) is an indigenous and important fish species, widely cultured in south China. However, part of individuals experienced retarded growth, the genetic basis of which has yet to be elucidated. In this study, whole-genome resequencing of 35 fast-growing and 35 retarded-growing south China carp were conducted to identify promising genes associated with retarded growth. Twelve candidate SNPs were detected and annotated to the Gpr75 gene, which has been reported to be related with body weight through regulating insulin homeostasis. RNA-seq analysis of muscle suggested that differentially expressed genes were significantly enriched in the insulin signaling pathway. Additionally, the fasting serum insulin level was significantly lower while the blood glucose level was significantly higher in the retarded-growing group. Our preliminary study provides insights into the genetic basis underlying the retarded growth and may facilitate further genetic improvement of south China carp.

分类号：

  • 相关文献
作者其他论文 更多>>

微信小程序