Research Progress on Multiplexed Pathogen Detection Using Optical Biosensors

文献类型： 外文期刊

第一作者： Wu, Yue

作者： Wu, Yue;Xu, Xing;Zhu, Yinchu;Wang, Xingbo;Zhou, Xin;Zhou, Weidong;Wan, Jiaxin;Li, Xiangjun

作者机构：

关键词： multiple pathogens; optical biosensors; microfluidic devices; nucleic acid amplification; nanomaterials

期刊名称：BIOSENSORS-BASEL （ 影响因子：5.6； 五年影响因子：5.7 ）

ISSN：

年卷期： 2025 年 15 卷 6 期

页码：

收录情况： SCI

摘要： The rapid and precise identification of multiple pathogens is critical for ensuring food safety, controlling epidemics, diagnosing diseases, and monitoring the environment. However, traditional detection methods are hindered by complex workflows, the need for skilled operators, and reliance on sophisticated equipment, making them unsuitable for rapid, on-site testing. Optical biosensors, known for their rapid analysis, portability, high sensitivity, and multiplexing capabilities, offer a promising solution for simultaneous multi-pathogenic identification. This paper explores recent advancements in the utilization of optical biosensors for multiple pathogenic detection. First, it provides an overview of key sensing principles, focusing on colorimetric, fluorescence-based, surface-enhanced Raman scattering (SERS), and surface plasmon resonance (SPR) techniques, as well as their applications in pathogenic detection. Then, the research progress and practical applications of optical biosensors for multiplex pathogenic detection are discussed in detail from three perspectives: microfluidic devices, nucleic acid amplification technology (NAAT), and nanomaterials. Finally, the challenges presented by optical biosensing technologies in multi-pathogen detection are discussed, along with future prospects and potential innovations in the field.

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