Signaling by the EPFL-ERECTA family coordinates female germline specification through the BZR1 family in Arabidopsis

文献类型： 外文期刊

第一作者： Cai, Hanyang

作者： Cai, Hanyang;Huang, Youmei;Zhang, Man;Chai, Mengnan;Xi, Xinpeng;Aslam, Mohammad;Ma, Suzhuo;Su, Han;Liu, Kaichuang;Tian, Yaru;Zhu, Wenhui;Qi, Jingang;Qin, Yuan;Liu, Liping;Dresselhaus, Thomas;Zhang, Man;Wang, Lulu;Qin, Yuan

作者机构：

期刊名称：PLANT CELL （ 影响因子：11.6； 五年影响因子：12.9 ）

ISSN： 1040-4651

年卷期： 2023 年 35 卷 5 期

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收录情况： SCI

摘要： In most flowering plants, the female germline is initiated in the subepidermal L2 layer of ovule primordia forming a single megaspore mother cell (MMC). How signaling from the L1 (epidermal) layer could contribute to the gene regulatory network (GRN) restricting MMC formation to a single cell is unclear. We show that EPIDERMAL PATTERNING FACTOR-like (EPFL) peptide ligands are expressed in the L1 layer, together with their ERECTA family (ERf) receptor kinases, to control female germline specification in Arabidopsis thaliana. EPFL-ERf dependent signaling restricts multiple subepidermal cells from acquiring MMC-like cell identity by activating the expression of the major brassinosteroid (BR) receptor kinase BRASSINOSTEROID INSENSITIVE 1 and the BR-responsive transcription factor BRASSINOZOLE RESISTANT 1 (BZR1). Additionally, BZR1 coordinates female germline specification by directly activating the expression of a nucleolar GTP-binding protein, NUCLEOSTEMIN-LIKE 1 (NSN1), which is expressed in early-stage ovules excluding the MMC. Mutants defective in this GRN form multiple MMCs resulting in a strong reduction of seed set. In conclusion, we uncovered a ligand/receptor-like kinase-mediated signaling pathway acting upstream and coordinating BR signaling via NSN1 to restrict MMC differentiation to a single subepidermal cell. A ligand/receptor-like kinase-mediated signaling pathway coordinates brassinosteroid signaling via the GTP-binding protein NUCLEOSTEMIN-LIKE 1 to restrict megaspore mother cell differentiation to a single subepidermal cell.

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