Strong mitonuclear discordance in the phylogeny of Neodermata and evolutionary rates of Polyopisthocotylea

文献类型： 外文期刊

第一作者： Zhang, Dong

作者： Zhang, Dong;Liu, Fei;Gusang, Qunzong;Tso, Sonam;Xue, Shenggui;Zhu, Wen-Jin;Li, Zhenxin;Wu, Jihua;Wang, Gui-Tang;Zhang, Dong;Jakovlic, Ivan;Xiang, Chuan-Yu;Wu, Jihua;Zou, Hong;Wang, Gui-Tang;Zou, Hong;Wang, Gui-Tang;Liu, Fei;Zhang, Dong;Wang, Gui-Tang

作者机构：

关键词： Co-evolution; Flatworms; mtDNA; Numt; Parasitism; Phylogeny; Polystomatidea; Selection pressure

期刊名称：INTERNATIONAL JOURNAL FOR PARASITOLOGY （ 影响因子：4.0； 五年影响因子：3.8 ）

ISSN： 0020-7519

年卷期： 2024 年 54 卷 5 期

页码：

收录情况： SCI

摘要： The genomic evolution of Polyopisthocotylea remains poorly understood in comparison to the remaining three classes of Neodermata: Monopisthocotylea, Cestoda, and Trematoda. Moreover, the evolutionary sequence of major events in the phylogeny of Neodermata remains unresolved. Herein we sequenced the mitogenome and transcriptome of the polyopisthocotylean Diplorchis sp., and conducted comparative evolutionary analyses using nuclear (nDNA) and mitochondrial (mtDNA) genomic datasets of Neodermata. We found strong mitonuclear discordance in the phylogeny of Neodermata. Polyopisthocotylea exhibited striking mitonuclear discordance in relative evolutionary rates: the fastest-evolving mtDNA in Neodermata and a comparatively slowly-evolving nDNA genome. This was largely attributable to its very long stem branch in mtDNA topologies, not exhibited by the nDNA data. We found indications that the fast evolution of mitochondrial genomes of Polyopisthocotylea may be driven both by relaxed purifying selection pressures and elevated levels of directional selection. We identified mitochondria-associated genes encoded in the nuclear genome: they exhibited unique evolutionary rates, but not correlated with the evolutionary rate of mtDNA, and there is no evidence for compensatory evolution (they evolved slower than the rest of the genome). Finally, there appears to exist an exceptionally large (approximate to 6.3 kb) nuclear mitochondrial DNA segment (numt) in the nuclear genome of newly sequenced Diplorchis sp. A 30-end segment of the 16S rRNA gene encoded by the numt was expressed, suggesting that this gene acquired novel, regulatory functions after the transposition to the nuclear genome. In conclusion, Polyopisthocotylea appears to be the lineage with the fastest-evolving mtDNA sequences among all of Bilateria, but most of the substitutions were accumulated deep in the evolutionary history of this lineage. As the nuclear genome does not exhibit a similar pattern, the circumstances underpinning this evolutionary phenomenon remain a mystery. (c) 2024 Australian Society for Parasitology. Published by Elsevier Ltd. All rights reserved.

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