Simultaneous Determination of Active Clinical Components of Teicoplanin and Ramoplanin in Environmental Water by LC-MS/MS Coupled With Cascade Elution

文献类型： 外文期刊

第一作者： Jin, Hui

作者： Jin, Hui;Zhao, Cheng;Yin, Yi;Zheng, Guangming;Li, Lichun;Shan, Qi;Zhang, Meiyu;Wei, Linting;Shi, Xiaona;Huang, Heqing;Zhang, Wenjing;Liu, Shugui;Jin, Hui;Yin, Yi;Zheng, Guangming;Shan, Qi;Shi, Xiaona

作者机构：

关键词： teicoplanin; LC-MS/MS; cascade elution; environmental water; ramoplanin

期刊名称：FRONTIERS IN ENVIRONMENTAL SCIENCE （ 影响因子：5.411； 五年影响因子：6.313 ）

ISSN：

年卷期： 2021 年 9 卷

页码：

收录情况： SCI

摘要： A simple, sensitive, and simultaneous method was established and validated for the active clinical components of teicoplanin and ramoplanin in environmental water by LC-MS/MS coupled with cascade elution. Moreover, a cascade elution method, which was rapid, solvent-less, and high-extraction efficient was successfully proposed to realize the extraction and purification of seven targets in one step. Under optimized conditions, the method showed excellent linearity with the correlation (R-2) >= 0.998 in the range of 1.0-100.0 ng L-1. Low matrix effects and good recoveries which ranged from 86 to 114% were reached with RSDs lower than 3.0% for most targets. The limits of detection and limit of quantification were 0.1-1.3 and 0.3-4.0 ng L-1, respectively. This method was successfully applied for the determination of teicoplanin and ramoplanin in water samples from the Pearl River and the South China Sea. TA2-2,3 was quantified in only one sample with the concentration of 8.0 ng L-1.

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